Clinical manifestations and diagnosis of Legionella infection
- Victor L Yu, MD
Victor L Yu, MD
- Professor of Medicine
- University of Pittsburgh Medical Center
- Janet E Stout, PhD
Janet E Stout, PhD
- Director, Special Pathogens Laboratory
- Research Associate Professor, University of Pittsburgh
- Nieves Sopena Galindo, MD
Nieves Sopena Galindo, MD
- Assistant Professor of Medicine
- Universitat Autònoma de Barcelona
Since the organism was first recognized in 1976 during an outbreak at an American Legion Convention in Philadelphia, Legionella has been identified as a relatively common cause of both community-acquired and hospital-acquired pneumonia.
Legionellosis refers to the two clinical syndromes caused by bacteria of the genus Legionella:
●Legionnaires' disease is the more common syndrome of pneumonia caused by Legionella species
●Pontiac fever is an acute, febrile, self-limited illness that has been linked to Legionella species
The clinical manifestations and diagnosis of Legionella infection will be reviewed here. The epidemiology, pathogenesis, treatment, and prevention of this entity are discussed separately. (See "Epidemiology and pathogenesis of Legionella infection" and "Treatment and prevention of Legionella infection".)
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- CLINICAL MANIFESTATIONS
- Legionnaires' disease
- - Symptoms
- - Physical examination
- - Laboratory findings
- - Chest radiograph
- - Clinical clues for the diagnosis
- Pontiac fever
- Extrapulmonary disease
- SPECIFIC LABORATORY DIAGNOSIS
- Culture on selective media
- Urinary antigen testing
- DFA staining
- Polymerase chain reaction
- Approach to diagnosis
- SUMMARY AND RECOMMENDATIONS