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Clinical features, evaluation, and treatment of retroperitoneal soft tissue sarcoma

John T Mullen, MD, FACS
Thomas F DeLaney, MD
Section Editors
Robert Maki, MD, PhD
Russell S Berman, MD
Raphael E Pollock, MD
Deputy Editor
Diane MF Savarese, MD


Sarcomas are malignant tumors that arise from skeletal and extraskeletal connective tissues, including the peripheral nervous system. The majority of soft tissue sarcomas (STS) present in the extremities; however, many other sites can be affected, including the retroperitoneum, chest wall, head and neck, and subcutaneous tissues.

The treatment of STS arising in the retroperitoneum will be reviewed here. A general discussion of the diagnostic evaluation and staging of STS, treatment of localized STS at other sites, local and systemic therapy for metastatic disease, treatment of desmoid tumors (which may present in intraabdominal and abdominal wall sites), and gastrointestinal stromal tumors (GIST; mesenchymal tumors that usually present in the wall of the gastrointestinal tract but occasionally present in extravisceral abdominal locations) are presented elsewhere:

(See "Clinical presentation, histopathology, diagnostic evaluation, and staging of soft tissue sarcoma", section on 'Introduction'.)

(See "Overview of multimodality treatment for primary soft tissue sarcoma of the extremities and chest wall".)

(See "Treatment of locally recurrent and unresectable, locally advanced soft tissue sarcoma of the extremities".)

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Literature review current through: Nov 2017. | This topic last updated: Mar 10, 2017.
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