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Clinical and laboratory aspects of platelet transfusion therapy

Shan Yuan, MD
Dennis Goldfinger, MD
Section Editor
Arthur J Silvergleid, MD
Deputy Editor
Jennifer S Tirnauer, MD


Hemostasis depends on an adequate number of functional platelets, together with an intact coagulation (clotting factor) system. This topic covers the logistics of platelet use and the indications for platelet transfusion in adults. The approach to the bleeding patient, refractoriness to platelet transfusion, and platelet transfusion in neonates are discussed elsewhere.

(See "Approach to the adult patient with a bleeding diathesis".)

(See "Refractoriness to platelet transfusion therapy".)

(See "Clinical manifestations, evaluation, and management of neonatal thrombocytopenia", section on 'Platelet transfusion'.)


There are two ways that platelets can be collected: by isolation from a unit of donated blood, or by apheresis from a donor in the blood bank.

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Literature review current through: Nov 2017. | This topic last updated: Dec 15, 2017.
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