Classification of primary cutaneous lymphomas
- Rein Willemze, MD
Rein Willemze, MD
- Professor and Chairman, Department of Dermatology
- Leiden University Medical Center
Primary cutaneous lymphomas are a heterogeneous group of T cell and B cell neoplasms that present in the skin without any evidence of extracutaneous disease at the time of diagnosis. In the last two decades, multiple classification systems have been used for these conditions. These include:
●European Organization for Research and Treatment of Cancer (EORTC) classification
●World Health Organization (WHO) classification 2001
●WHO-EORTC classification 2005To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
- Willemze R. Thirty years of progress in cutaneous lymphoma research. G Ital Dermatol Venereol 2012; 147:515.
- Willemze R, Kerl H, Sterry W, et al. EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. Blood 1997; 90:354.
- Grange F, Hedelin G, Joly P, et al. Prognostic factors in primary cutaneous lymphomas other than mycosis fungoides and the Sézary syndrome. The French Study Group on Cutaneous Lymphomas. Blood 1999; 93:3637.
- Fink-Puches R, Zenahlik P, Bäck B, et al. Primary cutaneous lymphomas: applicability of current classification schemes (European Organization for Research and Treatment of Cancer, World Health Organization) based on clinicopathologic features observed in a large group of patients. Blood 2002; 99:800.
- World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues, Jaffe ES, Harris NL, Stein H, Vardiman JW (Eds), IARC Press, Lyon 2001.
- Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105:3768.
- Zinzani PL, Quaglino P, Pimpinelli N, et al. Prognostic factors in primary cutaneous B-cell lymphoma: the Italian Study Group for Cutaneous Lymphomas. J Clin Oncol 2006; 24:1376.
- Senff NJ, Hoefnagel JJ, Jansen PM, et al. Reclassification of 300 primary cutaneous B-Cell lymphomas according to the new WHO-EORTC classification for cutaneous lymphomas: comparison with previous classifications and identification of prognostic markers. J Clin Oncol 2007; 25:1581.
- Khamaysi Z, Ben-Arieh Y, Izhak OB, et al. The applicability of the new WHO-EORTC classification of primary cutaneous lymphomas to a single referral center. Am J Dermatopathol 2008; 30:37.
- World Health Organization Classification of Tumours of Hematopoietic and Lymphoid Tissue, Swerdlow SH, Campo E, Harris NL, et al. (Eds), IARC Press, Lyon 2008.
- Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 2016; 127:2375.
- Willemze R, Jansen PM, Cerroni L, et al. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood 2008; 111:838.
- CUTANEOUS T CELL LYMPHOMAS
- Mycosis fungoides
- Sézary syndrome
- Adult T cell leukemia-lymphoma
- Primary cutaneous CD30+ lymphoproliferative disorders
- Subcutaneous panniculitis-like T cell lymphoma
- Extranodal NK/T cell lymphoma, nasal type
- Primary cutaneous peripheral T cell lymphoma, rare subtypes
- - Primary cutaneous gamma-delta T cell lymphoma
- - Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T cell lymphoma
- - Primary cutaneous acral CD8+ T cell lymphoma
- - Primary cutaneous CD4+ small/medium T cell lymphoproliferative disorder
- CUTANEOUS B CELL LYMPHOMAS
- Primary cutaneous marginal zone lymphoma
- Primary cutaneous follicle center lymphoma
- Primary cutaneous diffuse large B cell lymphoma, leg type