Chronic complications and age-related comorbidities in people with hemophilia
- W Keith Hoots, MD
W Keith Hoots, MD
- Director, Division of Blood Diseases and Resources
- National Heart, Lung and Blood Institute
- National Institutes of Health, Bethesda, Maryland
- Amy D Shapiro, MD
Amy D Shapiro, MD
- Medical Director
- Indiana Hemophilia and Thrombosis Center
- Adjunct Professor of Pediatrics
- Michigan State University
Hemophilia A (factor VIII [factor 8] deficiency) and hemophilia B (factor IX [factor 9] deficiency) are X-linked inherited coagulation factor deficiencies. The availability of factor replacement products has dramatically improved care for individuals with these conditions, resulting in dramatic improvements in life expectancy. However, as people with hemophilia live longer, they are more likely to develop chronic complications of hemophilic bleeding as well as age-related comorbidities such as heart disease and cancer, and many of the treatments for heart disease, cancer, and other conditions also increase the risk of bleeding.
This topic review discusses the management of these chronic complications and age-related comorbidities in people with hemophilia.
Separate topic reviews discuss diagnosis, routine care including factor prophylaxis, treatment of bleeding, surgery, inhibitor eradication, and genetics of hemophilia.
●Diagnosis – (See "Clinical manifestations and diagnosis of hemophilia".)
●Comprehensive care including factor prophylaxis – (See "Hemophilia A and B: Routine management including prophylaxis".)
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- CHRONIC COMPLICATIONS
- Other bleeding sequelae
- HIV and HCV infection
- Inhibitor development
- AGE-RELATED COMORBIDITIES
- Cardiovascular disease
- Chronic kidney disease
- Life expectancy
- Quality of life
- Causes of death
- SOCIETY GUIDELINES
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS