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Chronic complications and age-related comorbidities in people with hemophilia

W Keith Hoots, MD
Amy D Shapiro, MD
Section Editor
Lawrence LK Leung, MD
Deputy Editor
Jennifer S Tirnauer, MD


Hemophilia A (factor VIII [factor 8] deficiency) and hemophilia B (factor IX [factor 9] deficiency) are X-linked inherited coagulation factor deficiencies. The availability of factor replacement products has dramatically improved care for individuals with these conditions, resulting in dramatic improvements in life expectancy. However, as people with hemophilia live longer, they are more likely to develop chronic complications of hemophilic bleeding as well as age-related comorbidities such as heart disease and cancer, and many of the treatments for heart disease, cancer, and other conditions also increase the risk of bleeding.

This topic review discusses the management of these chronic complications and age-related comorbidities in people with hemophilia.

Separate topic reviews discuss diagnosis, routine care including factor prophylaxis, treatment of bleeding, surgery, inhibitor eradication, and genetics of hemophilia.

Diagnosis – (See "Clinical manifestations and diagnosis of hemophilia".)

Comprehensive care including factor prophylaxis – (See "Hemophilia A and B: Routine management including prophylaxis".)

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Literature review current through: Dec 2017. | This topic last updated: Jun 21, 2017.
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