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Chagas disease in the immunosuppressed host

Caryn Bern, MD, MPH
Section Editor
Peter F Weller, MD, MACP
Deputy Editor
Elinor L Baron, MD, DTMH


Chagas disease is caused by infection with the protozoan parasite Trypanosoma cruzi; the major manifestations are Chagas cardiomyopathy and gastrointestinal disease [1].

Issues related to Chagas in the setting of immunosuppression are reviewed here. Issues relating to acute and chronic Chagas infection are discussed separately. (See "Chagas disease: Acute and congenital Trypanosoma cruzi infection" and "Chagas disease: Chronic Trypanosoma cruzi infection".)

Issues related to epidemiology and prevention of Chagas disease are discussed separately. (See "Chagas disease: Epidemiology and prevention".)

Issues related to cardiac and gastrointestinal Chagas are discussed separately. (See "Chagas heart disease: Clinical manifestations and diagnosis" and "Chagas heart disease: Treatment and prognosis" and "Chagas gastrointestinal disease".)


Forms of Chagas disease in immunosuppressed hosts include reactivation of T. cruzi infection (in HIV-infected patients and patients on immunosuppressive medications) and donor-derived infection in organ transplant recipients.

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Literature review current through: Oct 2017. | This topic last updated: Sep 06, 2017.
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