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Cervical intraepithelial neoplasia: Reproductive effects of treatment

Maija Jakobsson, MD, PhD
Errol R Norwitz, MD, PhD, MBA
Section Editors
Barbara Goff, MD
Vincenzo Berghella, MD
Deputy Editor
Sandy J Falk, MD, FACOG


Cervical intraepithelial neoplasia (CIN) is a precursor to cervical cancer that is managed with either surveillance (cervical cytology and colposcopy) or treatment. Treatments for CIN include ablative or excisional cervical procedures. These treatments are often performed in reproductive-age women and may impact future fertility and pregnancy outcome. Awareness of reproductive risks associated with CIN treatment allows clinicians and patients to choose the optimal treatment method and to address subsequent reproductive issues.

CIN is also referred to as cervical dysplasia or cervical squamous intraepithelial lesions (CSIL). (See "Cervical intraepithelial neoplasia: Terminology, incidence, pathogenesis, and prevention", section on 'Terminology'.)

Reproductive effects of CIN treatment are reviewed here. General principles of CIN management and techniques for CIN treatment are discussed separately. (See "Cervical intraepithelial neoplasia: Management of low-grade and high-grade lesions" and "Cervical intraepithelial neoplasia: Procedures for cervical conization" and "Cervical intraepithelial neoplasia: Ablative therapies".)


There are two main categories of cervical intraepithelial neoplasia (CIN) treatment, excision and ablation. In excisional procedures (also referred to as conization; procedures include cold knife conization, loop electrosurgical excision procedure [LEEP], and laser conization), a segment of the cervix is removed and examined histologically. In ablative procedures (techniques include cryotherapy, laser, cold coagulation, diathermy), the tissue is destroyed, but remains in place; no histologic confirmation of the diagnosis is performed.

LEEP and cold knife conization are the most commonly used excisional methods; cryotherapy is the most commonly used ablative therapy. Laser conization and ablation are used less frequently, since they require expensive and bulky equipment. Diathermy and cold coagulation ablation are rarely used.

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Literature review current through: Nov 2017. | This topic last updated: Nov 29, 2016.
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