Cervical adenocarcinoma in situ
- Marcela G del Carmen, MD
Marcela G del Carmen, MD
- Department of Obstetrics, Gynecology and Reproductive Biology
- Harvard Medical School
- Medical Director
- Massachusetts General Physicians Organization
- John O Schorge, MD
John O Schorge, MD
- Chief, Gynecologic Oncology
- Massachusetts General Hospital
Adenocarcinoma in situ of the uterine cervix is a premalignant glandular condition. Adenocarcinoma in situ is the only known precursor to cervical adenocarcinoma, and appropriate management can prevent the occurrence of invasive disease in many cases . The usual interval between clinically detectable adenocarcinoma in situ and early invasion appears to be at least five years, suggesting ample opportunity for screening and intervention [2,3].
Glandular neoplasia of the uterine cervix is less common than squamous neoplasia, comprising one quarter of all annual cervical cancers diagnoses in the United States . Over the past few decades, however, the incidence of adenocarcinoma in situ and invasive adenocarcinoma has increased .
The diagnosis and management of cervical adenocarcinoma in situ are reviewed here. Related topics are discussed separately, including:
●Glandular cells on cervical cytology (see "Cervical cytology: Evaluation of atypical and malignant glandular cells")
●Invasive adenocarcinoma of the cervix (see "Invasive cervical cancer: Epidemiology, risk factors, clinical manifestations, and diagnosis" and "Invasive cervical adenocarcinoma")To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- EPIDEMIOLOGY AND RISK FACTORS
- CLINICAL FEATURES
- Cervical cytology
- Pelvic examination
- Colposcopy, biopsy, and endocervical curettage
- DIFFERENTIAL DIAGNOSIS
- POSTDIAGNOSTIC EVALUATION
- Evaluation of coexistent squamous neoplasia
- Clinical approach
- - Procedure
- - Posthysterectomy follow-up
- - Outcome
- Fertility preservation
- - Conization margin status
- Negative margin
- Positive margin
- - Postconization follow-up
- - Outcome
- AIS or adenocarcinoma
- Reproductive outcomes
- PREGNANT WOMEN
- SUMMARY AND RECOMMENDATIONS