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Cervical adenocarcinoma in situ

Marcela G del Carmen, MD
John O Schorge, MD
Section Editor
Barbara Goff, MD
Deputy Editor
Sandy J Falk, MD, FACOG


Adenocarcinoma in situ of the uterine cervix is a premalignant glandular condition. Adenocarcinoma in situ is the only known precursor to cervical adenocarcinoma, and appropriate management can prevent the occurrence of invasive disease in many cases [1]. The usual interval between clinically detectable adenocarcinoma in situ and early invasion appears to be at least five years, suggesting ample opportunity for screening and intervention [2,3].

Glandular neoplasia of the uterine cervix is less common than squamous neoplasia, comprising one quarter of all annual cervical cancers diagnoses in the United States [4]. Over the past few decades, however, the incidence of adenocarcinoma in situ and invasive adenocarcinoma has increased [5].

The diagnosis and management of cervical adenocarcinoma in situ are reviewed here. Related topics are discussed separately, including:

Glandular cells on cervical cytology (see "Cervical cytology: Evaluation of atypical and malignant glandular cells")

Invasive adenocarcinoma of the cervix (see "Invasive cervical cancer: Epidemiology, risk factors, clinical manifestations, and diagnosis" and "Invasive cervical adenocarcinoma")

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Literature review current through: Dec 2017. | This topic last updated: Jul 11, 2016.
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