Comparison of ceftazidime concentrations in bile and serum

Antimicrob Agents Chemother. 1983 Jul;24(1):104-6. doi: 10.1128/AAC.24.1.104.

Abstract

Biliary excretion of ceftazidime, a new broad-spectrum cephalosporin, was studied in two groups of patients after administration of a 2-g dose intravenously. Group A included 10 patients in whom ceftazidime levels in bile were measured during cholecystectomy. Group B included 10 patients with indwelling biliary tubes in whom ceftazidime levels in bile and serum were simultaneously measured at 0.5, 1, 2, 4, 6, and 8 h after administration of the drug. Although ceftazidime levels were variable, they exceeded the minimal inhibitory concentrations of most biliary tract pathogens in both groups.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Bile / metabolism*
  • Biliary Tract Surgical Procedures
  • Ceftazidime
  • Cephalosporins / blood
  • Cephalosporins / metabolism*
  • Female
  • Humans
  • Male
  • Middle Aged

Substances

  • Cephalosporins
  • Ceftazidime