Abstract
We describe a recent case of Stevens-Johnson Syndrome. A 49-year-old man was admitted to the Intensive Care Unit of an Anaesthesia and Resuscitation Department because of a Fournier gangrene that derived in a sepsis, ventilator-associated pneumonia, and renal failure. He was under treatment with cefepime and suffered a generalized status epilepticus, so started treatment with phenytoin. The next day he developed a "maculous cutaneous eruption in trunk and lower limbs" compatible with a Stevens-Johnson Syndrome. Stevens-Johnson Syndrome is a very severe and potentially fatal multiorganic disease, especially when present in critically ill patients, with a strong drug-related etiology, especially with antiepileptic drugs.
MeSH terms
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Anti-Bacterial Agents / adverse effects*
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Anticonvulsants / adverse effects*
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Anticonvulsants / therapeutic use
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Cefepime
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Cephalosporins / adverse effects*
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Critical Illness
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Fournier Gangrene / complications
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Fournier Gangrene / drug therapy
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Humans
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Kidney Failure, Chronic / complications
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Male
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Middle Aged
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Phenytoin / adverse effects*
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Phenytoin / therapeutic use
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Pneumonia, Ventilator-Associated / complications
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Pneumonia, Ventilator-Associated / drug therapy
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Sepsis / complications
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Sepsis / drug therapy
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Status Epilepticus / chemically induced
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Status Epilepticus / drug therapy
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Stevens-Johnson Syndrome / etiology
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Stevens-Johnson Syndrome / therapy*
Substances
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Anti-Bacterial Agents
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Anticonvulsants
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Cephalosporins
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Phenytoin
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Cefepime