Low plasma cefepime levels in critically ill septic patients: pharmacokinetic modeling indicates improved troughs with revised dosing

Antimicrob Agents Chemother. 1999 Oct;43(10):2559-61. doi: 10.1128/AAC.43.10.2559.

Abstract

The pharmacokinetics of a 2-g bolus of cefepime were measured in critically ill patients with normal renal function. Variable and low trough plasma drug concentrations were found, and 8 of 10 patients had levels below the MIC at which 50% of the isolates are inhibited for Pseudomonas aeruginosa. Computer simulations predicted that continuous infusion and shorter dosing intervals would increase trough levels.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / pharmacokinetics*
  • Cefepime
  • Cephalosporins / administration & dosage
  • Cephalosporins / blood
  • Cephalosporins / pharmacokinetics*
  • Computer Simulation
  • Critical Illness
  • Female
  • Humans
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Pseudomonas aeruginosa / drug effects

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Cefepime