Causes of thrombocytopenia in children
- Donald L Yee, MD
Donald L Yee, MD
- Associate Professor of Pediatrics
- Baylor College of Medicine
- Section Editors
- Donald H Mahoney, Jr, MD
Donald H Mahoney, Jr, MD
- Section Editor — Pediatric Hematology
- Professor of Pediatrics
- Baylor College of Medicine
- Lawrence LK Leung, MD
Lawrence LK Leung, MD
- Editor-in-Chief — Hematology
- Section Editor — Disorders of Hemostasis and Coagulation
- Professor of Medicine
- Stanford University School of Medicine
Thrombocytopenia is defined as a platelet count of <150,000/microL. It is clinically suspected when there is a history of easy bruising or bleeding, or it may present as an incidental finding during routine evaluation or during investigations performed for other reasons.
Causes of thrombocytopenia in children will be reviewed here. Causes of neonatal thrombocytopenia in neonates differ somewhat and are reviewed separately. (See "Causes of neonatal thrombocytopenia".)
The approach to evaluating a child with unexplained thrombocytopenia and/or bleeding symptoms and the details of specific causes of thrombocytopenia (eg, immune thrombocytopenia, leukemia, aplastic anemia) are discussed in separate topic reviews:To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- PLATELET DESTRUCTION
- Immune-mediated causes
- - Immune thrombocytopenia
- - Autoimmune disorders
- - Drug-induced thrombocytopenia
- Nonimmune causes
- - Platelet activation and consumption
- - Mechanical destruction
- - Sequestration and trapping
- IMPAIRED PLATELET PRODUCTION
- Nutritional deficiencies
- Bone marrow failure or infiltration
- Genetic causes of defective thrombopoiesis
- - Small platelets
- - Normal sized platelets
- - Large or giant platelets