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Causes of primary hypogonadism in males

Peter J Snyder, MD
Section Editor
Alvin M Matsumoto, MD
Deputy Editor
Kathryn A Martin, MD


Hypogonadism in a man refers to a decrease in one or both of the two major functions of the testes: sperm production and testosterone production. These abnormalities usually result from disease of the testes (primary hypogonadism) or disease of the pituitary or hypothalamus (secondary hypogonadism). In occasional cases, however, a defect in the ability to respond to testosterone is the cause of hypogonadism. (See "Diagnosis and treatment of disorders of the androgen receptor" and "Steroid 5-alpha-reductase 2 deficiency".)

The distinction between primary and secondary hypogonadism is made by measurement of the serum concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH):

The patient has primary hypogonadism if the serum testosterone concentration and the sperm count are below normal and the serum LH and FSH concentrations are above normal

The patient has secondary hypogonadism if the serum testosterone concentration and the sperm count are subnormal and the serum LH and FSH concentrations are normal or reduced

Primary hypogonadism differs from secondary hypogonadism in two ways:

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Literature review current through: Sep 2017. | This topic last updated: Apr 18, 2017.
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