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Medline ® Abstract for Reference 28

of 'Candida osteoarticular infections'

Candida arthritis in a premature infant treated successfully with oral fluconazole for six months.
Weigl JA
Ann Acad Med Singapore. 2000 Mar;29(2):253-5.
INTRODUCTION: Candida arthritis in premature infants is a rare condition mainly treated with parenteral amphotericin B.
CLINICAL PICTURE: Arthritis 9 weeks after birth. The infection resulted out of colonisation at birth and fungaemia at day 6 and day 13 of life.
TREATMENT: Oral fluconazole for 6 months (5 mg/kg/day after loading with 7 mg/kg/day).
OUTCOME: Full remission.
CONCLUSIONS: Oral fluconazole is an alternative to parenteral amphotericin B in the treatment of premature infants, but proof of absorption and an extended treatment period according to prematurity might be warranted.
Klinik für Allgemeine Pädiatrie, Kiel, Germany. weigl@pediatrics.uni-kiel.de