Effect of bismuth subsalicylate on chronic diarrhea in childhood: a preliminary report

Rev Infect Dis. 1990 Jan-Feb:12 Suppl 1:S36-40. doi: 10.1093/clinids/12.supplement_1.s36.

Abstract

Stools collected from 39 infants and children with chronic nonspecific diarrhea and from 10 age-matched controls were examined for bile acid content with use of gas-liquid chromatography. Values were correlated with stool color. Mean concentration of bile acids in green stools (7.7 +/- 1.52 mg/g dry weight) was significantly higher than that in brown stools (3.76 +/- 0.7 mg/g dry weight) and in control stools (1.42 +/- 0.35 mg/g dry weight). In patients with green diarrhea, treatments with cholestyramine and bismuth subsalicylate (Pepto-Bismol) were equally effective in decreasing stool frequency, with the latter being more effective in decreasing water content. Patients with brown stools had an insignificant response to therapy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bile Acids and Salts / analysis
  • Bismuth / therapeutic use*
  • Child, Preschool
  • Cholestyramine Resin / therapeutic use
  • Chromatography, Gas
  • Chronic Disease
  • Diarrhea / drug therapy*
  • Feces / analysis
  • Humans
  • Infant
  • Organometallic Compounds / therapeutic use*
  • Salicylates / therapeutic use*

Substances

  • Bile Acids and Salts
  • Organometallic Compounds
  • Salicylates
  • Cholestyramine Resin
  • bismuth subsalicylate
  • Bismuth