Barrett's esophagus: Evaluation with autofluorescence endoscopy
- Jacques J Bergman, MD, PhD
Jacques J Bergman, MD, PhD
- Professor of Gastrointestinal Endoscopy
- Head of Endoscopy
- Department of Gastroenterology and Hepatology
- Academic Medical Center Amsterdam
Barrett's esophagus (BE) is the most important risk factor for esophageal adenocarcinoma, the incidence of which has been rising rapidly over the past few decades. Standard endoscopic imaging provides little detail of the mucosal surface, making it impossible to distinguish specialized intestinal epithelium from gastric-type metaplasia or to recognize dysplastic epithelium.
Better imaging modalities have the potential to improve detection of BE and surveillance for dysplasia and cancer. Many new endoscopic techniques continue to be developed including magnification endoscopy, chromoendoscopy, optical coherence tomography, narrow band imaging, and autofluorescence endoscopy, but none is used routinely in clinical practice.
This topic review will summarize experience with autofluorescence endoscopy. General approaches to diagnosis and management of BE are discussed separately. (See "Barrett's esophagus: Epidemiology, clinical manifestations, and diagnosis" and "Barrett's esophagus: Surveillance and management".)
LIGHT-TISSUE INTERACTION AND AUTOFLUORESCENCE
Several interactions are possible when a photon of light (excitation light) comes into contact with tissue:
●The photon may be reflected immediately.To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- LIGHT-TISSUE INTERACTION AND AUTOFLUORESCENCE
- Autofluorescence for distinguishing tissue types
- AUTOFLUORESCENCE SPECTROSCOPY AND ENDOSCOPY
- Light-induced fluorescence spectroscopy
- Autofluorescence endoscopy
- - Fiberoptic fluorescence endoscopy
- - Video autofluorescence imaging
- INFORMATION FOR PATIENTS