Baclofen-induced toxicity in renal disease with neurotoxicity and skin rash

Proc (Bayl Univ Med Cent). 2019 Jun 21;32(3):425-426. doi: 10.1080/08998280.2019.1618659. eCollection 2019 Jul.

Abstract

Baclofen is approved by the Food and Drug Administration for spasticity and is also used off-label for trigeminal neuralgia, cluster headache, and substance abuse dependency. Baclofen is 90% renally excreted and has a variable threshold for toxicity in patients with chronic kidney disease. We present a case of accidental overdose of baclofen in a 58-year-old woman with intractable trigeminal neuralgia. She presented with baclofen neurotoxicity symptoms including confusion and tremors and had a morbilliform rash in the dorsum of both hands. This simultaneous presentation is rare and has never been reported. Her symptoms resolved after hemodialysis treatment.

Keywords: Baclofen toxicity; morbilliform rash; neurotoxicity.

Publication types

  • Case Reports