Baclofen-induced morbiliform rashes: a case series

J Clin Pharmacol. 2011 Dec;51(12):1733-4. doi: 10.1177/0091270010385936. Epub 2010 Nov 30.

Abstract

Baclofen is a gamma amino butyric acid (GABA) derivative that is a specific agonist at GABA-B receptors. Initially used in the treatment of spasticity, it is now being used in the treatment of alcohol dependence. Although it has several known adverse effects, incidence of rashes developing due to baclofen is very rare, and morbiliform rashes due to baclofen, an exceedingly rare adverse effect, has been reported only once before. We report a case series of 4 patients who developed morbiliform rashes after initiation of baclofen.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Alcoholism / drug therapy
  • Baclofen / adverse effects*
  • Exanthema / chemically induced*
  • Female
  • GABA-B Receptor Agonists / adverse effects*
  • Humans
  • Male

Substances

  • GABA-B Receptor Agonists
  • Baclofen