Baclofen withdrawal following removal of an intrathecal baclofen pump despite oral baclofen replacement

J Toxicol Clin Toxicol. 2003;41(1):83-5. doi: 10.1081/clt-120018277.

Abstract

Intrathecal baclofen is used as a muscle relaxant and antispasmodic in cases of spasticity resulting from central nervous system trauma. The baclofen withdrawal syndrome may include hyperthermia, tachycardia, hypertension, seizures, altered mental status, and psychomotor agitation. We report a case in which the removal of a baclofen pump lead tothe development of severe withdrawal symptoms despite oral baclofen replacement therapy. In order to avoid the development of withdrawal, adequate doses of GABA agonist agents should be administered immediately prior to, and following, baclofen pump removal.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Baclofen / administration & dosage*
  • Baclofen / adverse effects*
  • Baclofen / therapeutic use
  • GABA Agonists / therapeutic use
  • GABA-A Receptor Agonists
  • Hemodynamics / drug effects
  • Humans
  • Injections, Spinal
  • Male
  • Muscle Relaxants, Central / administration & dosage*
  • Muscle Relaxants, Central / adverse effects*
  • Muscle Relaxants, Central / therapeutic use
  • Muscle Spasticity / drug therapy
  • Muscle Spasticity / etiology
  • Quadriplegia / complications
  • Substance Withdrawal Syndrome / physiopathology*
  • Substance Withdrawal Syndrome / therapy

Substances

  • GABA Agonists
  • GABA-A Receptor Agonists
  • Muscle Relaxants, Central
  • Baclofen