Azathioprine-Associated Complete NK Cell Deficiency

J Clin Immunol. 2017 Aug;37(6):514-516. doi: 10.1007/s10875-017-0414-6. Epub 2017 Jun 22.

Authors

Amir B Orandi¹, Tiphanie P Vogel², Molly P Keppel¹, Elizabeth C Utterson³, Megan A Cooper^{4

5}

Affiliations

¹ Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.
² Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, USA.
³ Department of Pediatrics, Division of Gastroenterology and Nutrition, Washington University School of Medicine, St. Louis, MO, USA.
⁴ Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA. Cooper_m@wustl.edu.
⁵ Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. Cooper_m@wustl.edu.

PMID: 28639167
DOI: 10.1007/s10875-017-0414-6

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Azathioprine / adverse effects
Azathioprine / therapeutic use*
CD56 Antigen / metabolism
Child, Preschool
Cytotoxicity, Immunologic
Drug-Related Side Effects and Adverse Reactions / diagnosis*
Female
Humans
Immunologic Deficiency Syndromes / diagnosis*
Immunologic Deficiency Syndromes / etiology
Immunophenotyping
Immunosuppressive Agents / adverse effects
Immunosuppressive Agents / therapeutic use*
Inflammatory Bowel Diseases / diagnosis*
Inflammatory Bowel Diseases / drug therapy
Inflammatory Bowel Diseases / immunology
K562 Cells
Killer Cells, Natural / drug effects
Killer Cells, Natural / immunology*
Methotrexate / therapeutic use
Remission Induction
Tumor Necrosis Factor-alpha / antagonists & inhibitors
Withholding Treatment

Substances

CD56 Antigen
Immunosuppressive Agents
Tumor Necrosis Factor-alpha
Azathioprine
Methotrexate