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Medline ® Abstract for Reference 36

of 'Autoimmune lymphoproliferative syndrome (ALPS): Clinical features and diagnosis'

36
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Autoimmune lymphoproliferative syndrome (ALPS): a case with congenital onset.
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Kahwash SB, Fung B, Savelli S, Bleesing JJ, Qualman SJ
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Pediatr Dev Pathol. 2007 Jul-Aug;10(4):315-9.
 
We describe a case of autoimmune lymphoproliferative syndrome (ALPS), which is very unusual with regard to a clinical onset soon after birth, and a clinical picture dominated by splenomegaly, jaundice, and consumptive peripheral blood cytopenias, with minimal lymphadenopathy. Our documented close follow up demonstrated initial involvement of the spleen, followed by involvement of the bone marrow and the peripheral blood. The patient underwent bone marrow transplant and is alive and well 20 months after diagnosis.
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Department of Laboratory Medicine, Columbus Children's Hospital, Columbus, OH 43205, USA. kahwashs@chi.osu.edu
PMID