Approach to adjuvant treatment of endometrial cancer
- Steven C Plaxe, MD
Steven C Plaxe, MD
- Professor, Reproductive Medicine
- Director, Gynecologic Oncology
- University of California, San Diego School of Medicine
- Arno J Mundt, MD
Arno J Mundt, MD
- Section Editor — Radiation Therapy
- Chairman of Radiation Oncology
- University of California, San Diego
- Section Editors
- Barbara Goff, MD
Barbara Goff, MD
- Section Editor — Gynecologic Oncology
- Director, Gynecologic Oncology
- University of Washington Medical Center
- Don S Dizon, MD, FACP
Don S Dizon, MD, FACP
- Section Editor – Gynecologic Oncology
- Head of Women's Cancers, Lifespan Cancer Institute
- Director of Medical Oncology, Rhode Island Hospital
- Associate Professor of Medicine, Warren Alpert Medical School of Brown University
The treatment of endometrial cancer following surgical staging is based on the risk of relapse and persistent disease, which is defined by the cancer stage at diagnosis and presence of prognostic factors. This topic will cover the risk stratification criteria for newly diagnosed endometrial cancer. The treatment by risk category is covered separately.
DEFINITION OF RISK BASED ON HISTOLOGY AND STAGE
For women with newly diagnosed endometrial cancer, treatment is stratified based on the risk of disease recurrence, which is characterized using the stage of disease (table 1), histology of the tumor, and other pathologic factors:To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- DEFINITION OF RISK BASED ON HISTOLOGY AND STAGE
- OTHER PROGNOSTIC FACTORS
- Lower uterine segment involvement
- Positive peritoneal cytology
- Older age
- Black women
- Molecular prognostic factors
- OVERVIEW OF TREATMENT
- Low-risk endometrial cancer
- Intermediate-risk endometrial cancer
- High-risk endometrial cancer
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS