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Antithrombotic therapy in patients with infective endocarditis

Thomas L Ortel, MD, PhD
William H Gaasch, MD
Section Editors
Lawrence LK Leung, MD
Daniel J Sexton, MD
Deputy Editor
Susan B Yeon, MD, JD, FACC


Management of antithrombotic therapy (anticoagulant and antiplatelet agents) in patients with infective endocarditis (IE) is challenging given the competing risks of embolism and intracerebral hemorrhage in this condition and limited evidence on the effects of therapy. Anticoagulant and antiplatelet therapy have not been shown to reduce the risk of embolism in IE. However, many patients with IE have indications for antithrombotic therapy, particularly patients with mechanical prosthetic valves. In such patients, the potential risks and benefits of antithrombotic therapy must be carefully weighed.

The use of anticoagulants and antiplatelet agents in patients with IE will be reviewed here. The treatment and complications of IE are presented separately.

(See "Infective endocarditis in injection drug users".)

(See "Antimicrobial therapy of native valve endocarditis".)

(See "Antimicrobial therapy of prosthetic valve endocarditis".)

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Literature review current through: Nov 2017. | This topic last updated: Aug 18, 2017.
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