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Antimicrobial therapy of prosthetic valve endocarditis

Adolf W Karchmer, MD
Section Editor
Stephen B Calderwood, MD
Deputy Editor
Elinor L Baron, MD, DTMH


The antimicrobial therapy of prosthetic valve endocarditis (PVE) will be reviewed here. The pathogenesis, microbiology, pathology, clinical features, diagnosis, prevention, and surgical management of PVE are discussed separately. (See "Epidemiology, clinical manifestations, and diagnosis of prosthetic valve endocarditis" and "Surgery for prosthetic valve endocarditis".)

Issues related to management of native valve endocarditis and infection associated with cardiac devices are discussed separately. (See "Antimicrobial therapy of native valve endocarditis" and "Surgery for left-sided native valve infective endocarditis" and "Infections involving cardiac implantable electronic devices".)


Management of prosthetic heart valve infection can be difficult; optimal treatment requires:

Identification of the causative microorganism

Selection of an effective bactericidal antimicrobial regimen

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Literature review current through: Nov 2017. | This topic last updated: Feb 07, 2017.
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