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Anticoagulant rodenticide poisoning: Management

Diane P Calello, MD
Section Editor
Michele M Burns, MD, MPH
Deputy Editor
James F Wiley, II, MD, MPH


This topic reviews the management of anticoagulant rodenticide poisoning.

The clinical manifestations and diagnosis of anticoagulant rodenticide poisoning and an overview of rodenticide poisonings other than anticoagulant rodenticides is provided separately. (See "Anticoagulant rodenticide poisoning: Clinical manifestations and diagnosis" and "Overview of rodenticide poisoning".)


Not all ingestions of anticoagulant rodenticides warrant medical evaluation. The need for medical evaluation is determined by the clinical circumstances and the toxicity of the exposure. We consider a nontoxic dose to be <1 mg. However, with most anticoagulant rodenticide ingestions, the exact amount is difficult to determine and the clinical circumstances and type of formulation ingested is used to determine if an exposure is potentially toxic. We encourage determination of toxicity and need for evaluation in consultation with a regional poison control center, whenever possible. (See 'Additional resources' below.)

Our approach to patients after exposure to long-acting or warfarin anticoagulant rodenticides are based upon the guideline published by the American Association of Poison Control Centers as follows [1]:

Emergency department evaluation – Immediate referral to an emergency department, regardless of estimated dose ingested or exposure, is warranted for all of the following patients:

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Literature review current through: Nov 2017. | This topic last updated: Sep 14, 2017.
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