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Medline ® Abstract for Reference 2

of 'Angiotensin converting enzyme inhibitors in acute myocardial infarction: Mechanisms of action'

Comparison of degrees of left ventricular dilation within three hours and up to six days after onset of first acute myocardial infarction.
Korup E, Dalsgaard D, Nyvad O, Jensen TM, Toft E, Berning J
Am J Cardiol. 1997;80(4):449.
Following an acute myocardial infarction (AMI) there is immediate deterioration of contractility in the infarcted left ventricular (LV) wall. This can be followed by regional dilation (expansion) as well as global remodeling. We examined 35 consecutive patients--with no history of myocardial ischemia--who were admitted to hospital within 3 hours after initial symptoms and with ST-segment changes on an electrocardiogram consistent with transmural ischemia. Echocardiography was performed at admission, and at 6 hours, 12 hours, 24 hours, 3 days, and 6 days after onset of the AMI. Within 3 hours after onset of symptoms an increase in both end-diastolic volume index (EDVI) and end-systolic volume index (ESVI) was found in both anterior and inferior infarcts when compared with healthy controls (mean +/- SD EDVI: 99 +/- 13 ml/m2 [anterior], 69 +/- 17 ml/m2 [inferior], 51 +/- 15 ml/m2 [controls], p<or = 0.00001; ESVI: 62 +/- 12 ml/m2 [anterior], 38 +/- 11 ml/m2 [inferior], 17 +/- 6 ml/m2 [controls], p<or = 0.00001). At all points in time, volumes were larger in anterior infarcts than in inferior infarcts (p<0.05). The volumes did not change during the 6 days (p>0.1). Thus, major LV dilation is present within 3 hours after onset of symptoms of first AMI. The dilation is more pronounced in anterior versus inferior infarcts. From 3 hours until day 6 no further changes in LV volumes occurred.
Department of Cardiology, Aalborg Hospital, Denmark.