Evaluating the Risk Factors for Hospital-Onset Clostridium difficile Infections in a Large Healthcare System

Clin Infect Dis. 2018 Jun 1;66(12):1957-1959. doi: 10.1093/cid/cix1112.

Abstract

In this multicenter retrospective cohort study of over 1 million patients at 150 US hospitals, proton pump inhibitors increased the odds of a patient having hospital-onset Clostridium difficile infection as did third and fourth generation cephalosporins, carbapenems, and piperacillin/tazobactam. These findings support appropriate prescribing of acid-suppression therapy and high-risk antibiotics.

Publication types

  • Evaluation Study
  • Multicenter Study

MeSH terms

  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Carbapenems / adverse effects*
  • Carbapenems / therapeutic use
  • Clostridioides difficile / isolation & purification
  • Clostridium Infections / epidemiology*
  • Cross Infection / epidemiology*
  • Cross Infection / microbiology
  • Female
  • Hospitals
  • Humans
  • Male
  • Odds Ratio
  • Proton Pump Inhibitors / adverse effects*
  • Retrospective Studies
  • Risk Factors
  • United States / epidemiology
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Proton Pump Inhibitors