Postantibiotic effects of ABT-773 and amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae

M M Neuhauser; J L Prause; L H Danziger; S L Pendland

doi:10.1128/AAC.45.12.3613-3615.2001

Postantibiotic effects of ABT-773 and amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae

Antimicrob Agents Chemother. 2001 Dec;45(12):3613-5. doi: 10.1128/AAC.45.12.3613-3615.2001.

Authors

M M Neuhauser¹, J L Prause, L H Danziger, S L Pendland

Affiliation

¹ The University of Houston College of Pharmacy, Department of Clinical Sciences and Administration, Houston, Texas, USA.

Abstract

This study determined the postantibiotic effect (PAE) of ABT-773 versus that of amoxicillin-clavulanate against clinical isolates of Streptococcus pneumoniae and Haemophilus influenzae. The PAEs of ABT-773 and amoxicillin-clavulanate ranged from 2.3 to 6.0 h and 0 to 2.2 h against S. pneumoniae and from 2.7 to 9.1 h and 0 to 0.8 h against H. influenzae, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amoxicillin-Potassium Clavulanate Combination / pharmacology*
Drug Resistance, Microbial
Drug Therapy, Combination / pharmacology*
Erythromycin / analogs & derivatives*
Erythromycin / pharmacology*
Haemophilus Infections / microbiology
Haemophilus influenzae / drug effects*
Haemophilus influenzae / genetics
Humans
Ketolides*
Microbial Sensitivity Tests
Pneumococcal Infections / microbiology
Streptococcus pneumoniae / drug effects*
Streptococcus pneumoniae / genetics

Substances

Ketolides
Erythromycin
Amoxicillin-Potassium Clavulanate Combination
cethromycin