Abstract
Although amiodarone appears to have few pro-arrhythmic effects, torsade de pointes (TdP) has been observed during long-term drug administration, usually in conjunction with electrolyte disturbances, a change in drug dosage, or concomitant drug therapy. We report two cases of amiodarone-induced TdP shortly after administration of a low dose of oral amiodarone, in the absence of predisposing factors.
MeSH terms
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Administration, Oral
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Adult
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Aged, 80 and over
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Amiodarone / administration & dosage
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Amiodarone / adverse effects*
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Anti-Arrhythmia Agents / administration & dosage
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Anti-Arrhythmia Agents / adverse effects*
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Atrial Fibrillation / complications*
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Atrial Fibrillation / drug therapy
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Atrial Fibrillation / physiopathology
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Cardiomyopathies / complications*
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Cardiomyopathies / drug therapy
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Cardiomyopathies / physiopathology
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Coronary Artery Disease / complications*
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Coronary Artery Disease / drug therapy
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Coronary Artery Disease / physiopathology
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Female
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Humans
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Syncope / complications*
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Syncope / drug therapy
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Syncope / physiopathology
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Time Factors
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Torsades de Pointes / chemically induced*
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Torsades de Pointes / drug therapy
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Torsades de Pointes / physiopathology
Substances
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Anti-Arrhythmia Agents
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Amiodarone