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Medline ® Abstract for Reference 48

of 'AIDS-related Kaposi sarcoma: Staging and treatment'

The appearance of Kaposi sarcoma during corticosteroid therapy.
Trattner A, Hodak E, David M, Sandbank M
Cancer. 1993;72(5):1779.
BACKGROUND: Four epidemiologic types of Kaposi sarcoma (KS) are known: classic KS, endemic African KS, epidemic or acquired immunodeficiency syndrome-related KS, and KS associated with immunosuppressive therapy. In most of the latter patients, KS was reported to have developed after organ transplantation, particularly renal transplantation. Thirty-nine patients who have not had a transplant have been reported to have KS associated with corticosteroid therapy.
METHODS: The authors studied 10 patients with the appearance of KS during corticosteroid therapy (6 men, 4 women; age range, 42-79 years) who were treated with corticosteroids for autoimmune disorders (5 patients), lymphoproliferative disorders (2 patients), and diseases unrelated to the immune system (3 patients).
RESULTS: Genetically programmed susceptibility to corticosteroid-related KS was suggested by the descent of the study patients as well as most of those reported previously. The prognosis was guarded in all the study patients.
CONCLUSIONS: Corticosteroids should be withdrawn to achieve clinical remission.
Department of Dermatology, Beilinson Medical Center, Petah Tiqva, Israel.