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Adjuvant treatment of intermediate-risk endometrial cancer

Heidi J Gray, MD
Section Editors
Barbara Goff, MD
Don S Dizon, MD, FACP
Arno J Mundt, MD
Deputy Editor
Sadhna R Vora, MD


Cancer of the endometrium is the most common gynecologic malignancy in developed countries and the second most common in developing countries. Endometrioid carcinoma is the most common histologic subtype and typically presents at an early stage with abnormal uterine bleeding. It is associated with a good prognosis. Other histologic types of endometrial carcinoma (eg, serous, clear cell) may not present with uterine bleeding and are typically diagnosed at more advanced stages. As a result, these other types are associated with a poorer prognosis.

The stage at diagnosis (table 1) and histologic subtype of endometrial carcinoma are used to assign risk for recurrent or persistent disease into low-, intermediate-, and high-risk. This review will focus on adjuvant treatment for patients with intermediate-risk endometrial cancer. An overview of endometrial cancer, including clinical features and an approach to diagnosis, an overview on the approach to adjuvant treatment, and treatment of low- and high-risk and advanced endometrial cancer are discussed separately.

(See "Overview of endometrial carcinoma".)

(See "Endometrial carcinoma: Clinical features and diagnosis".)

(See "Approach to adjuvant treatment of endometrial cancer".)

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Literature review current through: Nov 2017. | This topic last updated: Sep 07, 2017.
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