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Medline ® Abstract for Reference 36

of 'Acute and early HIV infection: Treatment'

Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients.
Yanik EL, Napravnik S, Hurt CB, Dennis A, Quinlivan EB, Sebastian J, Kuruc JD, Eron JJ
J Acquir Immune Defic Syndr. 2012;61(2):258.
The associations of acute HIV infection (AHI) and other predictors with transmitted drug resistance (TDR) prevalence were assessed in a cohort of HIV-infected, antiretroviral-naïve patients. AHI was defined as being seronegative with detectable HIV RNA. Binomial regression was used to estimate prevalence ratios and 95% confidence intervals for associations with TDR. Among 43 AHI patients, TDR prevalence was 20.9%, whereas prevalence was 8.6% among 677 chronically infected patients. AHI was associated with 1.9 times the prevalence of TDR (95% confidence intervals: 1.0 to 3.6) in multivariable analysis. AHI patients may represent a vanguard group that portends increasing TDR in the future.
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA. elizabeth_yanik@med.unc.edu