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Medline ® Abstract for Reference 31

of 'Acinetobacter infection: Epidemiology, microbiology, pathogenesis, clinical features, and diagnosis'

VEB-1 Extended-spectrum beta-lactamase-producing Acinetobacter baumannii, France.
Naas T, Coignard B, Carbonne A, Blanckaert K, Bajolet O, Bernet C, Verdeil X, Astagneau P, Desenclos JC, Nordmann P, French Nosocomial Infection Early Warning Investigation and Surveillance Network
Emerg Infect Dis. 2006;12(8):1214.
VEB-1 extended-spectrum beta-lactamase-producing Acinetobacter baumannii was responsible for an outbreak in hospitals in France. A national alert was triggered in September 2003 when 4 hospitals reported clusters of A. baumannii infection with similar susceptibility profiles. Case definitions and laboratory guidelines were disseminated, and prospective surveillance was implemented; strains were sent to a single laboratory for characterization and typing. From April 2003 through June 2004, 53 hospitals reported 290 cases of A. baumannii infection or colonization; 275 isolates were bla(VEB-1)-positive and clonally related. Cases were first reported in 5 districts of northern France, then in 10 other districts in 4 regions. Within a region, interhospital spread was associated with patient transfer. In northern France, investigation and control measures led to a reduction of reported cases after January 2004. The national alert enabled early control of new clusters, demonstrating the usefulness of early warning about antimicrobial drug resist.
Department of Bacteriology and Virology, Höpital de Bicêtre, 73 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre CEDEX, France. thierry.naas@bct.ap-hop-paris.fr