Abstract
Both rectal diclofenac and paracetamol are commonly used to treat acute postoperative pain in children but combining them to improve the quality of analgesia is controversial. This study aimed to detect whether the pre-operative combined administration of rectal diclofenac and paracetamol is superior to either drug alone. One hundred and eight patients were randomly assigned to receive either rectal diclofenac 1 mg.kg(-1) or paracetamol 40 mg.kg(-1) or their combination 1 h prior to surgery. In the first 24 h postoperatively, pain was assessed using the Wong and Baker Pain Scale. If the patients experienced a pain score of 2 or more, morphine was given. The total dose of morphine and number of doses required were recorded. Children who received the rectal diclofenac-paracetamol combination experienced a lower pain scale and a decreased need for morphine compared with children receiving each drug alone.
Publication types
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Randomized Controlled Trial
MeSH terms
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Acetaminophen / administration & dosage
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Acetaminophen / therapeutic use*
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Administration, Rectal
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Analgesics, Non-Narcotic / administration & dosage
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Analgesics, Non-Narcotic / therapeutic use*
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Analgesics, Opioid / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Blood Pressure / drug effects
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Child
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Child, Preschool
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Diclofenac / administration & dosage
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Diclofenac / therapeutic use*
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Double-Blind Method
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Drug Administration Schedule
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Drug Combinations
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Female
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Heart Rate / drug effects
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Hernia, Inguinal / surgery*
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Humans
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Male
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Morphine / administration & dosage
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Pain Measurement / methods
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Pain, Postoperative / prevention & control*
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Preanesthetic Medication / methods
Substances
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Analgesics, Non-Narcotic
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Analgesics, Opioid
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Anti-Inflammatory Agents, Non-Steroidal
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Drug Combinations
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Diclofenac
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Acetaminophen
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Morphine