Consult the medical resource doctors trust

UpToDate is one of the most respected medical information resources in the world, used by over 360,000 doctors and thousands of patients to find answers to medical questions.

  • Content written by a faculty of over 4,000 physicians from leading medical institutions
  • Unbiased: free of advertising or pharmaceutical funding
  • Evidence-based treatment recommendations
  • Continuously updated to incorporate new medical findings

Hoarseness in adults

INTRODUCTION

"Hoarseness" is a term often used to describe any change in voice quality. This reflects a variety of complaints including vocal tremor, weakness, fatigue, altered pitch, breathiness, or strained voice quality.

Hoarseness that lasts for more than two weeks requires a complete otolaryngolic examination to rule out potentially serious causes such as malignancy. This is particularly a concern in patients with a history of tobacco or alcohol use who are at high risk for cancer of the head and neck.

The approach to the adult who presents with hoarseness will be reviewed here.

LARYNGEAL ANATOMY AND PHYSIOLOGY

The main functions of the larynx are:

  • Phonation, which refers to production of a vocal tone at the level of the vocal folds. The quality of the tone is modified by resonation through the upper airway and sinonasal tract and articulated into speech.
  • Airway patency during respiration, and airway protection from ingested material during swallowing. The normal swallow mechanism includes laryngeal elevation, posterior deflection of the epiglottis, and closure of the true and false vocal folds.
  • Valsalva, or generation of increased pressure against a tightly closed glottis. This enables functions such as cough, straining, throat clearing, and defecation.

To continue reading this article you need to subscribe.

Read the rest of this article and others like it

The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. The use of this website is governed by the UpToDate Terms of Use (click here) ©2009 UpToDate, Inc.
References Top
  1. Citardi, MJ, Gracco, CL, Sasaki, CT. The anatomy of the human larynx. In: Diagnosis and Treatment of Voice Disorders, Rubin, JS, Sataloff, RT, Korovin, GS, Gould, WJ (Eds), Igaku-Shoin, New York, Tokyo 1995.
  2. Rosen, CA, Anderson, D, Murry, T. Evaluating hoarseness: keeping your patient's voice healthy. Am Fam Physician 1998; 57:2775.
  3. Diagnosis and Treatment of Voice Disorders. Rubin, JS, Sataloff, RT, Korovin, GS (Eds), Plural Publishing, San Diego, CA 2006.
  4. Reveiz, L, Cardona, AF, Ospina, EG. Antibiotics for acute laryngitis in adults. Cochrane Database Syst Rev 2007; :CD004783.
  5. Schalen, L, Christensen, P, Eliasson, I, et al. Inefficacy of penicillin V in acute laryngitis in adults. Evaluation from results of double-blind study. Ann Otol Rhinol Laryngol 1985; 94:14.
  6. Schalen, L, Eliasson, I, Kamme, C, Schalen, C. Erythromycin in acute laryngitis in adults. Ann Otol Rhinol Laryngol 1993; 102:209.
  7. Remacle, M, Lawson, G. Diagnosis and management of laryngopharyngeal reflux disease. Curr Opin Otolaryngol Head Neck Surg 2006; 14:143.
  8. Koufman, JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991; 101:1.
  9. Cherry, J, Margulies, SI. Contact ulcer of the larynx. Laryngoscope 1968; 78:1937.
  10. Ruotsalainen, JH, Sellman, J, Lehto, L, et al. Interventions for treating functional dysphonia in adults. Cochrane Database Syst Rev 2007; :CD006373.
  11. Bouchayer, M, Cornut, G. Microsurgery for benign lesions of the vocal folds. Ear Nose Throat J 1988; 67:446.
  12. Havas, T, Lowinger, D, Priestley, J. Unilateral vocal fold paralysis: Causes, options, and outcomes. Aust N Z J Surg 1999; 69:509.
  13. Randolph, GW, Kamani, D. The importance of preoperative laryngoscopy in patients undergoing thyroidectomy: voice, vocal cord function, and the preoperative detection of invasive thyroid malignancy. Surgery 2006; 139:357.
  14. Baron, EM, Soliman, AM, Gaughan, JP, et al. Dysphagia, hoarseness, and unilateral true vocal fold motion impairment following anterior cervical diskectomy and fusion. Ann Otol Rhinol Laryngol 2003; 112:921.
  15. Sulica, L. The natural history of idiopathic unilateral vocal fold paralysis: evidence and problems. Laryngoscope 2008; 118:1303.
  16. Ramadan, HH, Wax, MK, Avery, S. Outcome and changing cause of unilateral vocal cord paralysis. Otolaryngol Head Neck Surg 1998; 118:199.
  17. Rosenthal, LH, Benninger, MS, Deeb, RH. Vocal fold immobility: a longitudinal analysis of etiology over 20 years. Laryngoscope 2007; 117:1864.
  18. Ishman, SL, Halum, SL, Patel, NJ, et al. Management of vocal paralysis: a comparison of adult and pediatric practices. Otolaryngol Head Neck Surg 2006; 135:590.
  19. Yin, SS, Qiu, WW, Stucker, FJ, et al. Evaluation of bilateral vocal fold dysfunction: paralysis versus fixation, superior versus recurrent, and distal versus proximal to the laryngeal nerves. Am J Otolaryngol 1997; 18:9.
  20. Bosley, B, Rosen, CA, Simpson, CB, et al. Medial arytenoidectomy versus transverse cordotomy as a treatment for bilateral vocal fold paralysis. Ann Otol Rhinol Laryngol 2005; 114:922.
  21. Montgomery, WW, Montgomery, SK. Montgomery thyroplasty implant system. Ann Otol Rhinol Laryngol Suppl 1997; 170:1.
  22. Whurr, R, Nye, C, Lorch, M. Meta-analysis of botulinum toxin treatment of spasmodic dysphonia: a review of 22 studies. Int J Lang Commun Disord 1998; 33 Suppl:327.
  23. Troung, DD, Rontal, M, Rolnick, M, et al. Double-blind controlled study of botulinum toxin in adductor spasmodic dysphonia. Laryngoscope 1991; 101:630.
  24. Merati, AL, Heman-Ackah, YD, Abaza, M, et al. Common movement disorders affecting the larynx: a report from the neurolaryngology committee of the AAO-HNS. Otolaryngol Head Neck Surg 2005; 133:654.
  25. Sewall, GK, Jiang, J, Ford, CN. Clinical evaluation of Parkinson's-related dysphonia. Laryngoscope 2006; 116:1740.
  26. Kent, RD, Kent, JF, Weismer, G, et al. Impairment of speech intelligibility in men with amyotrophic lateral sclerosis. J Speech Hear Disord 1990; 55:721.
  27. Liu, WB, Xia, Q, Men, LN, et al. Dysphonia as a primary manifestation in myasthenia gravis (MG): a retrospective review of 7 cases among 1520 MG patients. J Neurol Sci 2007; 260:16.
  28. Ruotsalainen, J, Sellman, J, Lehto, L, Verbeek, J. Systematic review of the treatment of functional dysphonia and prevention of voice disorders. Otolaryngol Head Neck Surg 2008; 138:557.
  29. Thomas, PS, Geddes, DM, Barnes, PJ. Pseudo-steroid resistant asthma. Thorax 1999; 54:352.
  30. Christopher, KL, Wood RP, 2d, Eckert, RC, et al. Vocal-cord dysfunction presenting as asthma. N Engl J Med 1983; 308:1566.
  31. Fields, CL, Roy, TM, Ossorio, MA. Variable vocal cord dysfunction. South Med J 1992; 85:422.
  32. Schalen, L, Andersson, K. Differential diagnosis and treatment of psychogenic voice disorder. Clin Otolaryngol 1992; 17:225.
  33. Seifert, E, Kollbrunner, J. An update in thinking about nonorganic voice disorders. Arch Otolaryngol Head Neck Surg 2006; 132:1128.
  34. Bartels, H, Dikkers, FG, van der, Wal JE, et al. Laryngeal amyloidosis: localized versus systemic disease and update on diagnosis and therapy. Ann Otol Rhinol Laryngol 2004; 113:741.
  35. Alaani, A, Warfield, AT, Pracy, JP. Management of laryngeal amyloidosis. J Laryngol Otol 2004; 118:279.
  36. Motta, G, Salzano, FA, Motta, S, Staibano, S. CO(2)-laser treatment of laryngeal amyloidosis. J Laryngol Otol 2003; 117:647.
  37. Bachor, Bonkowsky, V, Hacki, T. Herpes simplex virus type I reactivation as a cause of a unilateral temporary paralysis of the vagus nerve. Eur Arch Otorhinolaryngol 1996; 253:297.
  38. Parano, E, Pavone, L, Musumeci, S, et al. Acute palsy of the recurrent laryngeal nerve complicating Epstein-Barr virus infection. Neuropediatrics 1996; 27:164.
white circle LOG IN
white circle DEMO