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Frailty

INTRODUCTION

As the population ages, recognition of frailty in older adults becomes increasingly important. The potential to tailor medical care for the older patient to prevent frailty, to intervene to improve outcomes, and to recognize when palliation is appropriate are important components of geriatric care.

Frailty is often conceptualized by health care providers as a state of late life decline and vulnerability characterized by weakness and decreased physiologic reserve. Frail older adults are less able to adapt to stressors such as acute illness or trauma. Their increased vulnerability leads to adverse outcomes including falls, institutionalization, disability, and death [1].

Most medical practitioners who care for older adults have noted a subset of patients who are clearly in a state of rapid decline, seemingly unrelated to a specific disease state. Other patients who are frail have more subtle signs and symptoms that can be easily overlooked.

Old age itself does not define frailty. Some patients, despite advanced age, may experience temporary disability related to illness or trauma, but rebound after recovery and return to their baseline. Others may appear robust but tolerate medical stress poorly, and never regain full function following illness or hospitalization. Still others are noted to have gradual but unrelenting functional decline in the absence of apparent stress factors.

Frail older adults present a challenge to clinicians because they usually present with an increased burden of symptoms, are often medically complex, and are less able to tolerate interventions of any kind. Clinician awareness of the frailty syndrome, its biologic basis, and the increased risk for adverse outcomes can improve care for this most vulnerable subset of patients.

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Last literature review version 18.2: May 2010
This topic last updated: February 22, 2010
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References
Top
  1. Fried, LP, Tangen, CM, Walston, J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56:M146.
  2. Hamerman, D. Toward an understanding of frailty. Ann Intern Med 1999; 130:945.
  3. Walston, J, Hadley, EC, Ferrucci, L, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 2006; 54:991.
  4. Ferrucci, L, Guralnik, JM, Studenski, S, et al. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J Am Geriatr Soc 2004; 52:625.
  5. Chin A, Paw MJ, Dekker, JM, Feskens, EJ, et al. How to select a frail elderly population? A comparison of three working definitions. J Clin Epidemiol 1999; 52:1015.
  6. Cigolle, CT, Ofstedal, MB, Tian, Z, Blaum, CS. Comparing models of frailty: the Health and Retirement Study. J Am Geriatr Soc 2009; 57:830.
  7. Newman, AB, Gottdiener, JS, Mcburnie, MA, et al. Associations of subclinical cardiovascular disease with frailty. J Gerontol A Biol Sci Med Sci 2001; 56:M158.
  8. Walston, J. Frailty--the search for underlying causes. Sci Aging Knowledge Environ 2004; 2004:pe4.
  9. Avila-Funes, JA, Amieva, H, Barberger-Gateau, P, et al. Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city study. J Am Geriatr Soc 2009; 57:453.
  10. Boyle, PA, Buchman, AS, Wilson, RS, et al. Physical frailty is associated with incident mild cognitive impairment in community-based older persons. J Am Geriatr Soc 2010; 58:248.
  11. Rothman, MD, Leo-Summers, L, Gill, TM. Prognostic significance of potential frailty criteria. J Am Geriatr Soc 2008; 56:2211.
  12. Ensrud, KE, Ewing, SK, Taylor, BC, et al. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med 2008; 168:382.
  13. Ensrud, KE, Ewing, SK, Cawthon, PM, et al. A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc 2009; 57:492.
  14. Kiely, DK, Cupples, LA, Lipsitz, LA. Validation and Comparison of Two Frailty Indexes: The MOBILIZE Boston Study. J Am Geriatr Soc 2009; 57:1532.
  15. Bandeen-Roche, K, Xue, QL, Ferrucci, L, et al. Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci 2006; 61:262.
  16. Ahmed, N, Mandel, R, Fain, MJ. Frailty: an emerging geriatric syndrome. Am J Med 2007; 120:748.
  17. Woods, NF, LaCroix, AZ, Gray, SL, et al. Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc 2005; 53:1321.
  18. Cawthon, PM, Marshall, LM, Michael, Y, et al. Frailty in older men: prevalence, progression, and relationship with mortality. J Am Geriatr Soc 2007; 55:1216.
  19. Morley, JE, Baumgartner, RN, Roubenoff, R, et al. Sarcopenia. J Lab Clin Med 2001; 137:231.
  20. Poehlman, ET, Toth, MJ, Fishman, PS, et al. Sarcopenia in aging humans: the impact of menopause and disease. J Gerontol A Biol Sci Med Sci 1995; 50 Spec No:73.
  21. O'Donnell, AB, Araujo, AB, McKinlay, JB. The health of normally aging men: The Massachusetts Male Aging Study (1987-2004). Exp Gerontol 2004; 39:975.
  22. Mohr, BA, Bhasin, S, Kupelian, V, et al. Testosterone, sex hormone-binding globulin, and frailty in older men. J Am Geriatr Soc 2007; 55:548.
  23. Nass, R, Thorner, MO. Impact of the GH-cortisol ratio on the age-dependent changes in body composition. Growth Horm IGF Res 2002; 12:147.
  24. Lanfranco, F, Gianotti, L, Giordano, R, et al. Ageing, growth hormone and physical performance. J Endocrinol Invest 2003; 26:861.
  25. Leng, SX, Cappola, AR, Andersen, RE, et al. Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty. Aging Clin Exp Res 2004; 16:153.
  26. Cappola, AR, Xue, QL, Ferrucci, L, et al. Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J Clin Endocrinol Metab 2003; 88:2019.
  27. Schmidt, M, Naumann, H, Weidler, C, et al. Inflammation and sex hormone metabolism. Ann N Y Acad Sci 2006; 1069:236.
  28. Varadhan, R, Walston, J, Cappola, AR, et al. Higher levels and blunted diurnal variation of cortisol in frail older women. J Gerontol A Biol Sci Med Sci 2008; 63:190.
  29. Puts, MT, Visser, M, Twisk, JW, et al. Endocrine and inflammatory markers as predictors of frailty. Clin Endocrinol (Oxf) 2005; 63:403.
  30. Montero-Odasso, M, Duque, G. Vitamin D in the aging musculoskeletal system: An authentic strength preserving hormone. Mol Aspects Med 2005; 26:203.
  31. Walston, J, McBurnie, MA, Newman, A, et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med 2002; 162:2333.
  32. Ershler, WB, Keller, ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med 2000; 51:245.
  33. Ershler, WB. Biological interactions of aging and anemia: a focus on cytokines. J Am Geriatr Soc 2003; 51:S18.
  34. Leng, S, Chaves, P, Koenig, K, Walston, J. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study. J Am Geriatr Soc 2002; 50:1268.
  35. Valenti, G, Denti, L, Maggio, M, et al. Effect of DHEAS on skeletal muscle over the life span: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 2004; 59:466.
  36. Wang, H, Casaburi, R, Taylor, WE, et al. Skeletal muscle mRNA for IGF-IEa, IGF-II, and IGF-I receptor is decreased in sedentary chronic hemodialysis patients. Kidney Int 2005; 68:352.
  37. Daley, MJ, Spinks, WL. Exercise, mobility and aging. Sports Med 2000; 29:1.
  38. Spirduso, WW, Cronin, DL. Exercise dose-response effects on quality of life and independent living in older adults. Med Sci Sports Exerc 2001; 33:S598.
  39. Keysor, JJ. Does late-life physical activity or exercise prevent or minimize disablement? A critical review of the scientific evidence. Am J Prev Med 2003; 25:129.
  40. Province, MA, Hadley, EC, Hornbrook, MC, et al. The effects of exercise on falls in elderly patients. A preplanned meta-analysis of the FICSIT Trials. Frailty and Injuries: Cooperative Studies of Intervention Techniques [see comments]. JAMA 1995; 273:1341.
  41. Roubenoff, R. Sarcopenia: a major modifiable cause of frailty in the elderly. J Nutr Health Aging 2000; 4:140.
  42. Fiatarone, MA, O'Neill, EF, Ryan, ND, et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 1994; 330:1769.
  43. Hunter, GR, McCarthy, JP, Bamman, MM. Effects of resistance training on older adults. Sports Med 2004; 34:329.
  44. Miller, ME, Rejeski, WJ, Reboussin, BA, et al. Physical activity, functional limitations, and disability in older adults. J Am Geriatr Soc 2000; 48:1264.
  45. Lamberts, SW, van den, Beld AW, van der, Lely AJ. The endocrinology of aging. Science 1997; 278:419.
  46. Tenover, JS. Androgen replacement therapy to reverse and/or prevent age-associated sarcopenia in men. Baillieres Clin Endocrinol Metab 1998; 12:419.
  47. Lamberts, SW. The somatopause: to treat or not to treat?. Horm Res 2000; 53 Suppl 3:42.
  48. Morley, JE, Kim, MJ, Haren, MT. Frailty and hormones. Rev Endocr Metab Disord 2005; 6:101.
  49. Ganz, DA, Fung, CH, Sinsky, CA, et al. Key elements of high-quality primary care for vulnerable elders. J Gen Intern Med 2008; 23:2018.
  50. Urdangarin, CF. Comprehensive Geriatric Assessment and Management. In: Assessing Older Persons, Kane, RL, Kane, RA (Eds), Oxford University Press, New York 2000.
  51. Walston, JD, Fried, LP. Frailty and its Implications for Care. In: Geriatric Palliative Care, Morrison, RS, Meir, DE (Eds), Oxford University Press, New York 2003.
  52. Maly, RC, Leake, B, Frank, JC, et al. Implementation of consultative geriatric recommendations: the role of patient-primary care physician concordance. J Am Geriatr Soc 2002; 50:1372.
  53. Stuck, AE, Siu, AL, Wieland, GD, et al. Comprehensive geriatric assessment: a meta-analysis of controlled trials. Lancet 1993; 342:1032.
  54. Eng, C, Pedulla, J, Eleazer, GP, et al. Program of All-inclusive Care for the Elderly (PACE): an innovative model of integrated geriatric care and financing. J Am Geriatr Soc 1997; 45:223.
  55. Mukamel, DB, Peterson, DR, Temkin-Greener, H, et al. Program characteristics and enrollees' outcomes in the Program of All-Inclusive Care for the Elderly (PACE). Milbank Q 2007; 85:499.
  56. Palmer, RM, Counsell, S, Landefeld, CS. Clinical intervention trials: the ACE unit. Clin Geriatr Med 1998; 14:831.
  57. Sager, MA, Franke, T, Inouye, SK, et al. Functional outcomes of acute medical illness and hospitalization in older persons. Arch Intern Med 1996; 156:645.
  58. Counsell, SR, Holder, CM, Liebenauer, LL, et al. Effects of a multi-component intervention on functional outcomes and process of care in hospitalized older patients: a randomized controlled trial of acute care for the elders (ACE) in a community hospital. J Am Geriatr Soc 2000; 48:1572.
  59. Goldberg, TH, Chavin, SI. Preventive medicine and screening in older adults. J Am Geriatr Soc 1997; 45:344.
  60. Walter, LC, Covinsky, KE. Cancer screening in elderly patients. A framework for individualized decision making. JAMA 2001; 285:2750.
Frailty Patient information: Testicular cancer