Contents: Laboratory medicine
Adrenal tests
  • Assays of the renin-angiotensin-aldosterone system in adrenal disease
  • Diagnosis of adrenal insufficiency in adults
  • Establishing the diagnosis of Cushing's syndrome
  • Measurement of ACTH; CRH; and other hypothalamic and pituitary peptides
  • Measurement of cortisol in serum and saliva
  • Measurement of urinary excretion of endogenous and exogenous glucocorticoids
Autoantibody tests
  • Anti-U1 RNP antibodies in mixed connective tissue disease
  • Antibodies to DNA, Sm, and RNP
  • Antiribosomal P protein antibodies
  • Clinical significance of anti-Ro/SSA and anti-La/SSB antibodies
  • Clinical spectrum of antineutrophil cytoplasmic antibodies
  • Definition and diagnosis of mixed connective tissue disease
  • Diagnosis of the antiphospholipid syndrome
  • Measurement and clinical significance of antinuclear antibodies
  • Miscellaneous antinuclear antibodies
  • Origin and utility of measurement of rheumatoid factors
  • Overview of the clinical manifestations of systemic sclerosis (scleroderma) in adults
  • Significance of a positive ANA in young women with symmetric arthralgias
Fluid and electrolyte tests
  • Approach to the adult with metabolic acidosis
  • Approach to the patient with hypertension and hypokalemia
  • Causes and treatment of hyperphosphatemia
  • Diagnosis and treatment of hypomagnesemia
  • Diagnosis and treatment of hypophosphatemia
  • Diagnosis of hyperkalemia and hypoaldosteronism (type 4 RTA)
  • Diagnosis of hypernatremia
  • Diagnosis of hypokalemia
  • Diagnosis of hyponatremia
  • Diagnostic approach to hypercalcemia
  • Diagnostic approach to hypocalcemia
  • Plasma osmolal gap
  • Regulation of magnesium balance
  • Relation between total and ionized plasma calcium concentration
  • Serum anion gap in conditions other than metabolic acidosis
  • Simple and mixed acid-base disorders
  • The Δanion gap/ΔHCO3 ratio in patients with metabolic acidosis
  • Urine electrolytes in diagnosis of metabolic alkalosis
  • Urine sodium versus urine chloride
Hematology tests
  • Approach to the adult patient with a bleeding diathesis
  • Approach to the adult patient with anemia
  • Approach to the adult patient with thrombocytopenia
  • Approach to the diagnosis of hemolytic anemia in the adult
  • Approach to the patient with eosinophilia
  • Approach to the patient with neutrophilia
  • Approach to the patient with thrombocytosis
  • Automated hematology instrumentation
  • Bone marrow aspiration and biopsy: Indications and technique
  • Causes and diagnosis of anemia due to iron deficiency
  • Clinical and laboratory aspects of platelet transfusion therapy
  • Clinical features and diagnosis of autoimmune hemolytic anemia: Warm agglutinins
  • Clinical features and treatment of autoimmune hemolytic anemia: Cold agglutinins
  • Clinical manifestations and diagnosis of immune (idiopathic) thrombocytopenic purpura in adults
  • Clinical use of coagulation tests
  • Diagnosis and treatment of vitamin B12 and folic acid deficiency
  • Diagnosis of sickle cell syndromes
  • Diagnostic approach to the patient with polycythemia
  • Diagnostic approach to the patient with suspected polycythemia vera
  • Evaluation of bone marrow aspirate smears
  • Evaluation of the peripheral blood smear
  • Mean corpuscular volume
  • Molecular diagnosis of inherited hemoglobin disorders
  • Monoclonal gammopathy of undetermined significance
  • Overview of neutropenia
  • Pathophysiology and diagnosis of iron overload syndromes
  • Platelet function testing
  • Prenatal testing for the hemoglobinopathies and thalassemias
  • Recognition of monoclonal proteins
Liver function tests
  • Alkaline phosphatase and other enzymatic measures of cholestasis
  • Approach to the patient with abnormal liver function tests
  • Clinical aspects of serum bilirubin determination
  • Diagnostic approach to the patient with jaundice or asymptomatic hyperbilirubinemia
  • Liver function tests that detect injury to hepatocytes
  • Patterns of plasma aspartate and alanine aminotransferase levels with and without liver disease
  • Tests of the liver's biosynthetic capacity
  • Tests of the liver's capacity to transport organic anions and metabolize drugs
Miscellaneous
  • Acute phase reactants
  • Cervical cytology: Interpretation of results
  • General principles in the use of immune globulin
  • Intravenous immune globulin in hematologic disorders
Pancreas function tests
  • Approach to the patient with elevated serum amylase or lipase
  • Clinical features and diagnosis of malabsorption
Pulmonary function tests
  • Arterial blood gases
  • Diffusing capacity for carbon monoxide
  • Overview of pulmonary function testing in adults
  • Oxygenation and mechanisms of hypoxemia
  • Pulse oximetry
  • Reference values for pulmonary function testing
  • Simple and mixed acid-base disorders
Renal function tests
  • Assessment of kidney function: Serum creatinine; BUN; and GFR
  • Calculation of the creatinine clearance
  • Drugs that elevate the serum creatinine concentration
  • Etiology and diagnosis of acute tubular necrosis and prerenal disease
  • Evaluation of isolated proteinuria in adults
  • Fractional excretion of sodium in acute kidney injury (acute renal failure)
  • Measurement of urinary protein excretion
  • Orthostatic or postural proteinuria
  • Serologic tests in the evaluation of nephrotic syndrome
  • The significance of urinary eosinophils
  • Urinalysis in the diagnosis of renal disease
  • Urine osmolality versus specific gravity
  • Urine sodium versus urine chloride
Tests for infections
  • Blood cultures for the detection of bacteremia
  • Microbiology specimen collection and transport
  • Sputum cultures for the evaluation of bacterial pneumonia
  • Urine sampling and culture in the diagnosis of urinary tract infection in adults
Tests of immune system
  • Human leukocyte antigens (HLA): A roadmap
  • Laboratory evaluation of the immune system
  • Overview and clinical assessment of the complement system
  • Pathogenesis of spondyloarthritis
Thyroid function tests
  • Diagnosis of and screening for hypothyroidism
  • Diagnosis of hyperthyroidism
  • Drug interactions with thyroid hormones
  • Euthyroid hyperthyroxinemia and hypothyroxinemia
  • Laboratory assessment of thyroid function
Transfusion medicine
  • Compatibility testing
  • Granulocyte transfusions
  • Laboratory testing of donated blood
  • The incompatible crossmatch
  • Use of red blood cells for transfusion
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