Clinical Podcasts

UpToDate faculty discuss important “What’s New” and “Practice Changing UpDates”, based on recent medical journal articles, in our clinical podcasts. Our contributors are recognized physician leaders in their fields and offer their expertise regarding each update and its impact on clinical practice. Each clinical podcast includes the most current clinical information available as of the release date listed.

Support for UpToDate Talk is provided by UpToDate, Wolters Kluwer. UpToDate is entirely funded by the subscriptions of its users and does not accept advertising or funding unrelated to subscriptions. The opinions in such podcasts are entirely those of the discussants, and these discussants are authors and editors for UpToDate. View the UpToDate conflict of interest policy.

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Metformin use in diabetes; Flexible sigmoidoscopy and colorectal cancer screening in older women

Date Released: Mar 22 2017

This episode features Dr. David Nathan, discussing clinical outcomes of metformin use in populations with chronic kidney disease, congestive heart failure, or chronic liver disease; and Dr. Chyke Doubeni, discussing the effectiveness of screening for colorectal cancer using flexible sigmoidoscopy in men and women at different age groups. Dr. Nancy Sokol hosts.

Dr. NathanDr. David Nathan is a Professor of Medicine at Harvard Medical School and Director of the Clinical Research Center and Diabetes Center at Massachusetts General Hospital in Boston.
Dr. DoubeniDr. Chyke Doubeni is Chair and Presidential Associate Professor in the Department of Family Medicine and Community Health at the Perelman School of Medicine, University of Pennsylvania.

Segment on metformin use (Dr. Nathan):

  1. Crowley MJ, Diamantidis CJ, McDuffie JR, et al. Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review. Ann Intern Med 2017; 166:191.

Segment on screening for colorectal cancer using flexible sigmoidoscopy (Dr. Doubeni):

  1. Holme Ø, Schoen RE, Senore C, et al. Effectiveness of flexible sigmoidoscopy screening in men and women and different age groups: pooled analysis of randomised trials. BMJ 2017; 356:i6673.

David M Nathan, MD Nothing to disclose

Chyke Doubeni, MD, FRCS, MPH Nothing to disclose

Determining CPR futility for out-of-hosp cardiac arrest; Hep C management in liver transplantation

Date Released: Mar 8 2017

In this episode, Dr. Charles Pozner discusses criteria for determining futility for resuscitation for out-of-hospital cardiac arrest and potential implications for organ donation; and Dr. Robert Brown discusses management of hepatitis C infection in patients undergoing liver transplantation.

Listen to the full podcast by pressing the Play Button below, or jump to the segment on determining CPR futility for out-of-hospital cardiac arrest, or the segment on hepatitis C management in liver transplantation. .

Dr. PoznerDr. Charles Pozner is an Associate Professor at Harvard Medical School, Medical Director of the STRATUS Center for Medical Simulation, and an emergency medicine physician at Brigham and Women’s Hospital in Boston.
Dr. BrownDr. Robert Brown is a Professor of Medicine and Clinical Chief of the Division of Gastroenterology and Hepatology at the Weill Cornell Medical Center in NYC.

Segment on futility of resuscitation following cardiac arrest (Dr. Pozner):

  1. Jabre P, Bougouin W, Dumas F, et al. Early Identification of Patients With Out-of-Hospital Cardiac Arrest With No Chance of Survival and Consideration for Organ Donation. Ann Intern Med 2016; 165:770.

Segment on management of Hepatitis C in patients undergoing liver transplantation (Dr. Brown):

  1. Levitsky J, Verna EC, O'Leary JG, et al. Perioperative Ledipasvir-Sofosbuvir for HCV in Liver-Transplant Recipients. N Engl J Med 2016; 375:2106.

Charles N Pozner, MD Nothing to disclose

Robert S Brown, Jr, MD, MPH Grant/Research/Clinical Trial Support: Gilead; Bristol-Myers Squibb; Janssen; AbbVie; Merck; [Hepatitis C, ALF (various direct-acting agents for HCV, bioartificial liver devices)]. Consultant/Advisory Boards: Gilead; Bristol-Myers Squibb; Janssen; AbbVie; Merck; Vital Therapies [Hepatitis B and C, ALF (various direct-acting agents for HCV, bioartificial liver devices)].

Adverse pregnancy outcomes associated with treatment for CIN; Prevention of egg allergy in infants

Date Released: Feb 22 2017

This episode features Dr. Barbara Goff, discussing a population-based study on adverse pregnancy outcomes associated with treatment for cervical intraepithelial neoplasia (CIN) (starts at 00:43); and Dr. David Fleischer, discussing data on early dietary egg introduction for the prevention of egg allergy in infants (starts at 15:32).

Listen to the full podcast by pressing the Play Button below, or jump to the segment on adverse pregnancy outcomes associated with treatment for CIN, or the segment on prevention of egg allergy in infants.

Dr. GoffDr. Barbara Goff is a Professor of Obstetrics and Gynecology and Director of the Division of Gynecologic Oncology at the University of Washington School of Medicine.
Dr. FleischerDr. David Fleischer is an Associate Professor of Pediatrics and Allergy at the University of Colorado School of Medicine and Director of the Food Challenge Unit at Children’s Hospital Colorado.

Segment on adverse pregnancy outcomes associated with treatment for CIN (Dr. Goff):

  1. Bjørge T, Skare GB, Bjørge L, et al. Adverse Pregnancy Outcomes After Treatment for Cervical Intraepithelial Neoplasia. Obstet Gynecol 2016; 128:1265.

Segment on prevention of egg allergy in infants (Dr. Fleischer):

  1. Natsume O, Kabashima S, Nakazato J, et al. Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial. Lancet 2017; 389:276.
  2. Palmer DJ, Sullivan TR, Gold MS, et al. Randomized controlled trial of early regular egg intake to prevent egg allergy. J Allergy Clin Immunol 2016.
  3. Wei-Liang Tan J, Valerio C, Barnes EH, et al. A randomized trial of egg introduction from 4 months of age in infants at risk for egg allergy. J Allergy Clin Immunol 2016.
  4. Bellach J, Schwarz V, Ahrens B, et al. Randomized placebo-controlled trial of hen's egg consumption for primary prevention in infants. J Allergy Clin Immunol 2016.

Close

Barbara Goff, MD Consultant/Advisory Boards: Roche Diagnostics [Biomarkers for ovarian cancer (HE4)]. Employment (Spouse): Lilly [General oncology (Gemcitabine, pemetrexed)] - No relevant conflict on topics.

David M Fleischer, MD Grant/Research/Clinical Trial Support: Monsanto Company [Food allergy]; Nestle Nutrition Institute [Food allergy]; DBV Technologies [Food allergies (Electrostatic immunotherapy patch)]; Aimmune Therapeutics [Food allergies (oral immunotherapy)]. Speaker's Bureau: Nestle Nutrition Institute [Food allergy]. Consultant/Advisory Boards: NIAID Coordinating Committee and Expert Panel, Update to the Food Allergy Guidelines, Prevention of Peanut Allergy [Food allergy]; Medical Advisory Board for the Food Allergy & Anaphylaxis Connection Team (FAACT) [Food allergy]; Medical Advisory Board for FARE [Food allergy]; Medical Advisory Council for the National Peanut Board [Food allergy]; DBV Technologies [Food allergy]’; Aimmune Therapeutics [Food allergy]; Intrommune Therapeutics [Food allergy]; Kaleo Pharma [Food allergy].

Syncope and pulmonary embolus; Treatment of vulvovaginal atrophy

Date Released: Feb 8 2017

This episode features Dr. Jess Mandel, discussing the prevalence of pulmonary embolism in patients hospitalized for syncope (starts at 00:54); and Dr. Robert Barbieri, discussing the potential role for a new topical drug, prasterone (DHEA), in the treatment of genitourinary syndrome of menopause (starts at 11:44). Dr. Nancy Sokol hosts.

Listen to the full podcast by pressing the Play Button below, or jump to the segment on syncope and pulmonary embolus, or the segment on treatment of vulvovaginal atrophy.

Dr. MandelDr. Jess Mandel is a Professor of Clinical Medicine at the University of California San Diego.
Dr. BarbieriDr. Robert Barbieri is a Professor of Obstetrics, Gynecology, and Reproductive Biology at Harvard Medical School.

Segment on syncope and pulmonary embolus (Dr. Mandel):

  1. Prandoni P, Lensing AW, Prins MH, et al. Prevalence of Pulmonary Embolism among Patients Hospitalized for Syncope. N Engl J Med 2016; 375:1524.

Segment on treatment of vulvovaginal atrophy (Dr. Barbieri):

  1. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm529641.htm (Accessed on November 18, 2016).
  2. Labrie F, Derogatis L, Archer DF, et al. Effect of Intravaginal Prasterone on Sexual Dysfunction in Postmenopausal Women with Vulvovaginal Atrophy. J Sex Med 2015; 12:2401.

Jess Mandel, MD Nothing to disclose

Robert L Barbieri, MD Nothing to disclose

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