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Medline ® Abstract for Reference 127

of 'Zika virus infection: An overview'

Increased rates of Guillain-Barrésyndrome associated with Zika virus outbreak in the Salvador metropolitan area, Brazil.
Styczynski AR, Malta JMAS, Krow-Lucal ER, Percio J, Nóbrega ME, Vargas A, Lanzieri TM, Leite PL, Staples JE, Fischer MX, Powers AM, Chang GJ, Burns PL, Borland EM, Ledermann JP, Mossel EC, Schonberger LB, Belay EB, Salinas JL, Badaro RD, Sejvar JJ, Coelho GE
PLoS Negl Trop Dis. 2017;11(8):e0005869. Epub 2017 Aug 30.
In mid-2015, Salvador, Brazil, reported an outbreak of Guillain-Barrésyndrome (GBS), coinciding with the introduction and spread of Zika virus (ZIKV). We found that GBS incidence during April-July 2015 among those≥12 years of age was 5.6 cases/100,000 population/year and increased markedly with increasing age to 14.7 among those≥60 years of age. We conducted interviews with 41 case-patients and 85 neighborhood controls and found no differences in demographics or exposures prior to GBS-symptom onset. A higher proportion of case-patients (83%) compared to controls (21%) reported an antecedent illness (OR 18.1, CI 6.9-47.5), most commonly characterized by rash, headache, fever, and myalgias, within a median of 8 days prior to GBS onset. Our investigation confirmed an outbreak of GBS, particularly in older adults, that was strongly associated with Zika-like illness and geo-temporally associated with ZIKV transmission, suggesting that ZIKV may result in severe neurologic complications.
National Center for Emerging Zoonotic and Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.