血清肌酐浓度倒数值与慢性肾脏疾病
- Author
- Anthony Bleyer, MD, MS
Anthony Bleyer, MD, MS
- Professor of Internal Medicine/Nephrology
- Wake Forest University School of Medicine
- Section Editors
- Gary C Curhan, MD, ScD
Gary C Curhan, MD, ScD
- Section Editor — Chronic Kidney Disease
- Professor of Medicine
- Harvard Medical School
- Richard H Sterns, MD
Richard H Sterns, MD
- Editor-in-Chief — Nephrology
- Section Editor — Fluid and Electrolytes
- Professor Emeritus
- University of Rochester School of Medicine and Dentistry
- Deputy Editor
- John P Forman, MD, MSc
John P Forman, MD, MSc
- Senior Deputy Editor — UpToDate
- Deputy Editor — Nephrology
- Assistant Professor of Medicine
- Harvard Medical School
- Translators
- 梅长林, 主任医师，教授
梅长林, 主任医师，教授
- 第二军医大学附属长征医院肾内科
引言
计算肌酐清除率来估计肾小球滤过率(glomerular filtration rate, GFR)的基础为肌酐自由滤过且不被重吸收。因此，如果忽略肌酐的分泌，所有滤过的肌酐[等于GFR和血清肌酐(serum creatinine, SCr)浓度之积]等于所有排泄的肌酐[等于尿肌酐(urine creatinine, UCr)浓度和尿流速率(V)之积]。因此：
GFR x SCr = UCr x V
GFR=(UCr x V)/ SCr
如果肌肉质量保持恒定，那么肌酐的产生将保持相对恒定，因此肌酐清除(UCr x V)也将保持相对恒定。因此，后面一个等式可以简化为GFR与SCr浓度的倒数呈正比。在临床上，随着时间监测SCr浓度的倒数值是评估肾功能随时间变化的有效方法。
利用SCr浓度倒数值来监测肾功能随时间变化所需的方法将总结在此。为帮助临床医生进行这项任务，我们还提供了一份图表。运用SCr浓度值和肌酐清除率来估计GFR的详细讨论(包括干扰肌酐分泌的药物或用于SCr测定的化验分析)参见其他专题。 (参见“肾功能的评估”)
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To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information or to purchase a personal subscription, click below on the option that best describes you:Literature review current through: 2017-06 . | This topic last updated: 2014-06-30.The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. The use of this website is governed by the UpToDate Terms of Use ©2017 UpToDate, Inc.References- Levey AS. Measurement of renal function in chronic renal disease. Kidney Int 1990; 38:167.
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