Medline ® Abstract for Reference 172
Methemoglobinemia caused by topical benzocaine.
Benzocaine-induced methemoglobinemia is a rare but life-threatening event. The use of topical benzocaine spray in a 77-year-old woman during endoscopic retrograde cholangiopancreatogram produced marked cyanosis and methemoglobin levels consistent with methemoglobinemia. Immediate recognition and prompt treatment of the disorder are essential to decrease morbidity and mortality.
Department of Pharmacy, Cleveland Clinic Hospital, Ft. Lauderdale, Florida 33308, USA.