UpToDate
Official reprint from UpToDate®
www.uptodate.com ©2017 UpToDate®

成年创伤患者院内处理概述

Author
Babak Sarani, MD, FACS, FCCM
Section Editor
Heidi L Frankel, MD, FACS
Deputy Editor
Kathryn A Collins, MD, PhD, FACS
Translators
汤文浩, 主任医师,教授

引言

在美国,创伤是44岁以下年龄人群的主要死因,也是45岁以上年龄人群的前5位死因之一。创伤性损伤患者的处理具有多种挑战。大多数患者在收入住院前都在急诊科接受了多学科评估、复苏和病情稳定的处理,也可能接受了手术干预。患者可能会因存在未发现的损伤,或因相关初始或后续的处理,而仍有并发症的风险。

本专题将对需住院的创伤患者的一般治疗和处理进行总结。急诊科的初始评估和治疗将单独讨论。特定创伤将单独在其他专题讨论。 (参见“成年创伤患者的院前急救”“成人腹部钝挫伤的初始评估和处理”“成人钝性胸部损伤的初步评估和处理”)

患者评估

持续的院内评估和监测对创伤患者的处理至关重要。对已经接受过损伤控制手术的患者和接受非手术性处理的损伤患者(如钝性脾损伤、肝损伤、十二指肠损伤或胰腺损伤)来讲尤其如此。识别创伤性损伤的完整范围需要准确的病史采集、熟练的体格检查以及及时正确地选用诊断检查。

全面病史采集 — 严重创伤患性损伤者在被送入急诊科时往往不能提供详细的既往病史,通常最初也可能无法从其他渠道(如家属或朋友)获得相关信息。因此,必须依靠收治入院的医师来获取患者的额外信息,包括既往病史、门诊用药、过敏史以及任何酒精和药物使用史。准确的病史信息除了对优化医学处理有价值以外,对评估患者预后也有价值。 (参见下文‘结局’)

获取导致损伤的情景的相关信息也非常重要,因为从高处跌落或车祸可能是由医学原因(如心律失常、低血糖症或脑卒中)引起,而殴打损伤则可能是家庭暴力的结果。此外,自我造成的损伤可能是心理障碍的表现,需要医生加以甄别,并予以治疗。

                                             

Subscribers log in here

To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information or to purchase a personal subscription, click below on the option that best describes you:
Literature review current through: 2017-06 . | This topic last updated: 2016-10-04.
The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. The use of this website is governed by the UpToDate Terms of Use ©2017 UpToDate, Inc.
References
Top
  1. MacKenzie EJ, Morris JA Jr, Edelstein SL. Effect of pre-existing disease on length of hospital stay in trauma patients. J Trauma 1989; 29:757.
  2. Soderstrom CA, Smith GS, Dischinger PC, et al. Psychoactive substance use disorders among seriously injured trauma center patients. JAMA 1997; 277:1769.
  3. Jurkovich GJ, Rivara FP, Gurney JG, et al. The effect of acute alcohol intoxication and chronic alcohol abuse on outcome from trauma. JAMA 1993; 270:51.
  4. Milzman DP, Soderstrom CA. Substance use disorders in trauma patients. Diagnosis, treatment, and outcome. Crit Care Clin 1994; 10:595.
  5. Biffl WL, Harrington DT, Cioffi WG. Implementation of a tertiary trauma survey decreases missed injuries. J Trauma 2003; 54:38.
  6. Richards CF, Mayberry JC. Initial management of the trauma patient. Crit Care Clin 2004; 20:1.
  7. Committee on Trauma of the American College of Surgeons. Advanced Trauma Life Support: Course for Physicians, 5th ed, American College of Surgeons, Chicago, 1993, p. 17.
  8. Yeh DD, Imam AM, Truong SH, et al. Incidental findings in trauma patients: dedicated communication with the primary care physician ensures adequate follow-up. World J Surg 2013; 37:2081.
  9. Pfeifer R, Pape HC. Missed injuries in trauma patients: A literature review. Patient Saf Surg 2008; 2:20.
  10. Giannakopoulos GF, Saltzherr TP, Beenen LF, et al. Missed injuries during the initial assessment in a cohort of 1124 level-1 trauma patients. Injury 2012; 43:1517.
  11. Kalemoglu M, Demirbas S, Akin ML, et al. Missed injuries in military patients with major trauma: original study. Mil Med 2006; 171:598.
  12. Brooks A, Holroyd B, Riley B. Missed injury in major trauma patients. Injury 2004; 35:407.
  13. Vles WJ, Veen EJ, Roukema JA, et al. Consequences of delayed diagnoses in trauma patients: a prospective study. J Am Coll Surg 2003; 197:596.
  14. Todd SR. Critical concepts in abdominal injury. Crit Care Clin 2004; 20:119.
  15. Enderson BL, Maull KI. Missed injuries. The trauma surgeon's nemesis. Surg Clin North Am 1991; 71:399.
  16. Sung CK, Kim KH. Missed injuries in abdominal trauma. J Trauma 1996; 41:276.
  17. Allen GS, Coates NE. Pulmonary contusion: a collective review. Am Surg 1996; 62:895.
  18. Cohn SM. Pulmonary contusion: review of the clinical entity. J Trauma 1997; 42:973.
  19. Wanek S, Mayberry JC. Blunt thoracic trauma: flail chest, pulmonary contusion, and blast injury. Crit Care Clin 2004; 20:71.
  20. CRASH-2 trial collaborators, Shakur H, Roberts I, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010; 376:23.
  21. Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ. Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg 2012; 147:113.
  22. Ouellet JF, Roberts DJ, Tiruta C, et al. Admission base deficit and lactate levels in Canadian patients with blunt trauma: are they useful markers of mortality? J Trauma Acute Care Surg 2012; 72:1532.
  23. Régnier MA, Raux M, Le Manach Y, et al. Prognostic significance of blood lactate and lactate clearance in trauma patients. Anesthesiology 2012; 117:1276.
  24. Thorson CM, Ryan ML, Van Haren RM, et al. Venous thromboembolism after trauma: a never event?*. Crit Care Med 2012; 40:2967.
  25. Bandle J, Shackford SR, Kahl JE, et al. The value of lower-extremity duplex surveillance to detect deep vein thrombosis in trauma patients. J Trauma Acute Care Surg 2013; 74:575.
  26. http://www.east.org/resources/traumacast-detail/23 (Accessed on April 28, 2016).
  27. Goldberg SR, Anand RJ, Como JJ, et al. Prophylactic antibiotic use in penetrating abdominal trauma: an Eastern Association for the Surgery of Trauma practice management guideline. J Trauma Acute Care Surg 2012; 73:S321.
  28. Smith BP, Fox N, Fakhro A, et al. "SCIP"ping antibiotic prophylaxis guidelines in trauma: The consequences of noncompliance. J Trauma Acute Care Surg 2012; 73:452.
  29. O'Donnell M, Weitz JI. Thromboprophylaxis in surgical patients. Can J Surg 2003; 46:129.
  30. Spain DA, Richardson JD, Polk HC Jr, et al. Venous thromboembolism in the high-risk trauma patient: do risks justify aggressive screening and prophylaxis? J Trauma 1997; 42:463.
  31. Geerts WH, Code KI, Jay RM, et al. A prospective study of venous thromboembolism after major trauma. N Engl J Med 1994; 331:1601.
  32. Velmahos GC, Kern J, Chan LS, et al. Prevention of venous thromboembolism after injury: an evidence-based report--part I: analysis of risk factors and evaluation of the role of vena caval filters. J Trauma 2000; 49:132.
  33. Meissner MH, Chandler WL, Elliott JS. Venous thromboembolism in trauma: a local manifestation of systemic hypercoagulability? J Trauma 2003; 54:224.
  34. Malinoski D, Ewing T, Patel MS, et al. Risk factors for venous thromboembolism in critically ill trauma patients who cannot receive chemical prophylaxis. Injury 2013; 44:80.
  35. Brakenridge SC, Henley SS, Kashner TM, et al. Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: a new paradigm for posttraumatic venous thromboembolism? J Trauma Acute Care Surg 2013; 74:1231.
  36. Brakenridge SC, Toomay SM, Sheng JL, et al. Predictors of early versus late timing of pulmonary embolus after traumatic injury. Am J Surg 2011; 201:209.
  37. Ginzburg E, Cohn SM, Lopez J, et al. Randomized clinical trial of intermittent pneumatic compression and low molecular weight heparin in trauma. Br J Surg 2003; 90:1338.
  38. Brasel KJ, Borgstrom DC, Weigelt JA. Cost-effective prevention of pulmonary embolus in high-risk trauma patients. J Trauma 1997; 42:456.
  39. Geerts WH, Jay RM, Code KI, et al. A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma. N Engl J Med 1996; 335:701.
  40. Upchurch GR Jr, Demling RH, Davies J, et al. Efficacy of subcutaneous heparin in prevention of venous thromboembolic events in trauma patients. Am Surg 1995; 61:749.
  41. Fisher CG, Blachut PA, Salvian AJ, et al. Effectiveness of pneumatic leg compression devices for the prevention of thromboembolic disease in orthopaedic trauma patients: a prospective, randomized study of compression alone versus no prophylaxis. J Orthop Trauma 1995; 9:1.
  42. Rosenthal D, Wellons ED, Levitt AB, et al. Role of prophylactic temporary inferior vena cava filters placed at the ICU bedside under intravascular ultrasound guidance in patients with multiple trauma. J Vasc Surg 2004; 40:958.
  43. Dossett LA, Adams RC, Cotton BA. Unwarranted national variation in the use of prophylactic inferior vena cava filters after trauma: an analysis of the National Trauma Databank. J Trauma 2011; 70:1066.
  44. Barrera LM, Perel P, Ker K, et al. Thromboprophylaxis for trauma patients. Cochrane Database Syst Rev 2013; :CD008303.
  45. Rogers FB, Cipolle MD, Velmahos G, et al. Practice management guidelines for the prevention of venous thromboembolism in trauma patients: the EAST practice management guidelines work group. J Trauma 2002; 53:142.
  46. Hirsh J, Raschke R. Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126:188S.
  47. Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133:381S.
  48. Kakkos SK, Caprini JA, Geroulakos G, et al. Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism in high-risk patients. Cochrane Database Syst Rev 2008; :CD005258.
  49. Kwiatt ME, Patel MS, Ross SE, et al. Is low-molecular-weight heparin safe for venous thromboembolism prophylaxis in patients with traumatic brain injury? A Western Trauma Association multicenter study. J Trauma Acute Care Surg 2012; 73:625.
  50. Saadeh Y, Gohil K, Bill C, et al. Chemical venous thromboembolic prophylaxis is safe and effective for patients with traumatic brain injury when started 24 hours after the absence of hemorrhage progression on head CT. J Trauma Acute Care Surg 2012; 73:426.
  51. Hoen S, Mazoit JX, Asehnoune K, et al. Hydrocortisone increases the sensitivity to alpha1-adrenoceptor stimulation in humans following hemorrhagic shock. Crit Care Med 2005; 33:2737.
  52. Roquilly A, Mahe PJ, Seguin P, et al. Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study. JAMA 2011; 305:1201.
  53. Berg GM, Spence M, Patton S, et al. Pressure ulcers in the trauma population: are reimbursement penalties appropriate? J Trauma Acute Care Surg 2012; 72:793.
  54. Tsuei BJ, Kearney PA. Hypothermia in the trauma patient. Injury 2004; 35:7.
  55. Shafi S, Elliott AC, Gentilello L. Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry. J Trauma 2005; 59:1081.
  56. Rudnick MR, Berns JS, Cohen RM, Goldfarb S. Contrast media-associated nephrotoxicity. Semin Nephrol 1997; 17:15.
  57. Deray G, Jacobs C. Radiocontrast nephrotoxicity. A review. Invest Radiol 1995; 30:221.
  58. Merten GJ, Burgess WP, Gray LV, et al. Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial. JAMA 2004; 291:2328.
  59. Biffl WL, Moore EE, Haenel JB. Nutrition support of the trauma patient. Nutrition 2002; 18:960.
  60. Cheatham ML, Safcsak K, Brzezinski SJ, Lube MW. Nitrogen balance, protein loss, and the open abdomen. Crit Care Med 2007; 35:127.
  61. Burlew CC, Moore EE, Cuschieri J, et al. Who should we feed? Western Trauma Association multi-institutional study of enteral nutrition in the open abdomen after injury. J Trauma Acute Care Surg 2012; 73:1380.
  62. Moore EE, Jones TN. Benefits of immediate jejunostomy feeding after major abdominal trauma--a prospective, randomized study. J Trauma 1986; 26:874.
  63. Dissanaike S, Pham T, Shalhub S, et al. Effect of immediate enteral feeding on trauma patients with an open abdomen: protection from nosocomial infections. J Am Coll Surg 2008; 207:690.
  64. Heyland DK, Dhaliwal R, Day AG, et al. REducing Deaths due to OXidative Stress (The REDOXS Study): Rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically-ill patients. Proc Nutr Soc 2006; 65:250.
  65. Todd SR, Gonzalez EA, Turner K, Kozar RA. Update on postinjury nutrition. Curr Opin Crit Care 2008; 14:690.
  66. Casaer MP, Hermans G, Wilmer A, Van den Berghe G. Impact of early parenteral nutrition completing enteral nutrition in adult critically ill patients (EPaNIC trial): a study protocol and statistical analysis plan for a randomized controlled trial. Trials 2011; 12:21.
  67. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Rice TW, Wheeler AP, et al. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA 2012; 307:795.
  68. Byrnes MC, Reicks P, Irwin E. Early enteral nutrition can be successfully implemented in trauma patients with an "open abdomen". Am J Surg 2010; 199:359.
  69. Cothren CC, Moore EE, Ciesla DJ, et al. Postinjury abdominal compartment syndrome does not preclude early enteral feeding after definitive closure. Am J Surg 2004; 188:653.
  70. Kudsk KA, Tolley EA, DeWitt RC, et al. Preoperative albumin and surgical site identify surgical risk for major postoperative complications. JPEN J Parenter Enteral Nutr 2003; 27:1.
  71. Bochicchio GV, Joshi M, Bochicchio KM, et al. Early hyperglycemic control is important in critically injured trauma patients. J Trauma 2007; 63:1353.
  72. Bochicchio GV, Salzano L, Joshi M, et al. Admission preoperative glucose is predictive of morbidity and mortality in trauma patients who require immediate operative intervention. Am Surg 2005; 71:171.
  73. Yendamuri S, Fulda GJ, Tinkoff GH. Admission hyperglycemia as a prognostic indicator in trauma. J Trauma 2003; 55:33.
  74. Bochicchio GV, Bochicchio KM, Joshi M, et al. Acute glucose elevation is highly predictive of infection and outcome in critically injured trauma patients. Ann Surg 2010; 252:597.
  75. Kerby JD, Griffin RL, MacLennan P, Rue LW 3rd. Stress-induced hyperglycemia, not diabetic hyperglycemia, is associated with higher mortality in trauma. Ann Surg 2012; 256:446.
  76. van Haarst EP, van Bezooijen BP, Coene PP, Luitse JS. The efficacy of serial physical examination in penetrating abdominal trauma. Injury 1999; 30:599.
  77. Brooks AJ, Rowlands BJ. Blunt abdominal injuries. Br Med Bull 1999; 55:844.
  78. Al-Mulhim AS, Mohammad HA. Non-operative management of blunt hepatic injury in multiply injured adult patients. Surgeon 2003; 1:81.
  79. Rotondo MF, Schwab CW, McGonigal MD, et al. 'Damage control': an approach for improved survival in exsanguinating penetrating abdominal injury. J Trauma 1993; 35:375.
  80. Schreiber MA. Damage control surgery. Crit Care Clin 2004; 20:101.
  81. Parr MJ, Alabdi T. Damage control surgery and intensive care. Injury 2004; 35:713.
  82. Chung SB, Lee SH, Kim ES, Eoh W. Incidence of deep vein thrombosis after spinal cord injury: a prospective study in 37 consecutive patients with traumatic or nontraumatic spinal cord injury treated by mechanical prophylaxis. J Trauma 2011; 71:867.
  83. Ho KM, Burrell M, Rao S, Baker R. Incidence and risk factors for fatal pulmonary embolism after major trauma: a nested cohort study. Br J Anaesth 2010; 105:596.
  84. Tuttle-Newhall JE, Rutledge R, Hultman CS, Fakhry SM. Statewide, population-based, time-series analysis of the frequency and outcome of pulmonary embolus in 318,554 trauma patients. J Trauma 1997; 42:90.
  85. O'Malley KF, Ross SE. Pulmonary embolism in major trauma patients. J Trauma 1990; 30:748.
  86. Spencer Netto F, Tien H, Ng J, et al. Pulmonary emboli after blunt trauma: timing, clinical characteristics and natural history. Injury 2012; 43:1502.
  87. Watkins TR, Nathens AB, Cooke CR, et al. Acute respiratory distress syndrome after trauma: development and validation of a predictive model. Crit Care Med 2012; 40:2295.
  88. Cook A, Norwood S, Berne J. Ventilator-associated pneumonia is more common and of less consequence in trauma patients compared with other critically ill patients. J Trauma 2010; 69:1083.
  89. Rello J, Ollendorf DA, Oster G, et al. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 2002; 122:2115.
  90. Cavalcanti M, Ferrer M, Ferrer R, et al. Risk and prognostic factors of ventilator-associated pneumonia in trauma patients. Crit Care Med 2006; 34:1067.
  91. Milzman DP, Boulanger BR, Rodriguez A, et al. Pre-existing disease in trauma patients: a predictor of fate independent of age and injury severity score. J Trauma 1992; 32:236.
  92. Winfield RD, Bochicchio GV. The critically injured obese patient: a review and a look ahead. J Am Coll Surg 2013; 216:1193.
  93. Liu T, Chen JJ, Bai XJ, et al. The effect of obesity on outcomes in trauma patients: a meta-analysis. Injury 2013; 44:1145.