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青少年及成人中的非痫性发作性疾病

Authors
Thien T Nguyen, MD, PhD
Peter W Kaplan, MB, FRCP
Section Editor
Timothy A Pedley, MD
Deputy Editor
April F Eichler, MD, MPH
Translators
周立春, 主任医师,副教授

引言

“痫性发作”是指大脑的神经元异常过度放电引起的体征和/或症状短暂出现。癫痫是以反复发作为特征的一种疾病。

据估计,癫痫在人群中的占比为0.5%-1%,但是在癫痫诊所和监测中心就诊的患者中,接近25%并无癫痫[1-4]。对于临床医生来说,识别这类可能类似于癫痫发作的短暂性非痫性事件很重要,以避免采用抗癫痫药物进行不必要的治疗,以及为了适时开始正确的治疗。

痫性发作的症状多种多样。因此,鉴别诊断将根据患者的具体临床表现而不同。显然不需要对任何一位患者考虑所有这些疾病。

可被误诊为癫痫的非痫性发作性事件在不同年龄组中也有明显差异(表 1)。本专题将总结青少年及年轻成人中的非痫性发作性疾病。这些诊断可被分为6大类:

晕厥

                                

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Literature review current through: 2017-06 . | This topic last updated: 2016-09-07.
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References
Top
  1. Benbadis SR, Allen Hauser W. An estimate of the prevalence of psychogenic non-epileptic seizures. Seizure 2000; 9:280.
  2. Scheepers B, Clough P, Pickles C. The misdiagnosis of epilepsy: findings of a population study. Seizure 1998; 7:403.
  3. Smith D, Defalla BA, Chadwick DW. The misdiagnosis of epilepsy and the management of refractory epilepsy in a specialist clinic. QJM 1999; 92:15.
  4. McDade G, Brown SW. Non-epileptic seizures: management and predictive factors of outcome. Seizure 1992; 1:7.
  5. Gavris MF, Khalighi K, Mascarenhas DA. Idiopathic cardiac asystole presenting as epileptic seizures. J Electrocardiol 2002; 35:279.
  6. Zaidi A, Clough P, Cooper P, et al. Misdiagnosis of epilepsy: many seizure-like attacks have a cardiovascular cause. J Am Coll Cardiol 2000; 36:181.
  7. Sheldon R, Rose S, Ritchie D, et al. Historical criteria that distinguish syncope from seizures. J Am Coll Cardiol 2002; 40:142.
  8. Hoefnagels WA, Padberg GW, Overweg J, Roos RA. Syncope or seizure? A matter of opinion. Clin Neurol Neurosurg 1992; 94:153.
  9. Cooper PN, Westby M, Pitcher DW, Bullock I. Synopsis of the National Institute for Health and Clinical Excellence Guideline for management of transient loss of consciousness. Ann Intern Med 2011; 155:543.
  10. Hadjikoutis S, O'Callaghan P, Smith PE. The investigation of syncope. Seizure 2004; 13:537.
  11. Aminoff MJ, Scheinman MM, Griffin JC, Herre JM. Electrocerebral accompaniments of syncope associated with malignant ventricular arrhythmias. Ann Intern Med 1988; 108:791.
  12. Rodrigues Tda R, Sternick EB, Moreira Mda C. Epilepsy or syncope? An analysis of 55 consecutive patients with loss of consciousness, convulsions, falls, and no EEG abnormalities. Pacing Clin Electrophysiol 2010; 33:804.
  13. Passman R, Horvath G, Thomas J, et al. Clinical spectrum and prevalence of neurologic events provoked by tilt table testing. Arch Intern Med 2003; 163:1945.
  14. Lin JT, Ziegler DK, Lai CW, Bayer W. Convulsive syncope in blood donors. Ann Neurol 1982; 11:525.
  15. Lempert T, Bauer M, Schmidt D. Syncope: a videometric analysis of 56 episodes of transient cerebral hypoxia. Ann Neurol 1994; 36:233.
  16. Brenner RP. Electroencephalography in syncope. J Clin Neurophysiol 1997; 14:197.
  17. Britton JW, Benarroch E. Seizures and syncope: anatomic basis and diagnostic considerations. Clin Auton Res 2006; 16:18.
  18. Rossetti AO, Dworetzky BA, Madsen JR, et al. Ictal asystole with convulsive syncope mimicking secondary generalisation: a depth electrode study. J Neurol Neurosurg Psychiatry 2005; 76:885.
  19. Britton JW, Ghearing GR, Benarroch EE, Cascino GD. The ictal bradycardia syndrome: localization and lateralization. Epilepsia 2006; 47:737.
  20. North KN, Ouvrier RA, Nugent M. Pseudoseizures caused by hyperventilation resembling absence epilepsy. J Child Neurol 1990; 5:288.
  21. David JE, Yale SH, Vidaillet HJ. Hyperventilation-induced syncope: no need to panic. Clin Med Res 2003; 1:137.
  22. Low, PA. Clinical autonomic disorders, 2nd ed, Lippincott-Raven, Philadelphia 1997.
  23. Eirís-Puñal J, Rodríguez-Núñez A, Fernández-Martínez N, et al. Usefulness of the head-upright tilt test for distinguishing syncope and epilepsy in children. Epilepsia 2001; 42:709.
  24. Chiesa V, Gardella E, Tassi L, et al. Age-related gender differences in reporting ictal fear: analysis of case histories and review of the literature. Epilepsia 2007; 48:2361.
  25. Johanson M, Valli K, Revonsuo A, Wedlund JE. Content analysis of subjective experiences in partial epileptic seizures. Epilepsy Behav 2008; 12:170.
  26. Coccaro EF, Posternak MA, Zimmerman M. Prevalence and features of intermittent explosive disorder in a clinical setting. J Clin Psychiatry 2005; 66:1221.
  27. Drake ME Jr, Hietter SA, Pakalnis A. EEG and evoked potentials in episodic-dyscontrol syndrome. Neuropsychobiology 1992; 26:125.
  28. Poceta, JS, Mitler, MM. Sleep disorders: Diagnosis and treatment, Humana Press, Totowa, New Jersey 1998.
  29. Malow BA. Sleep and epilepsy. Neurol Clin 2005; 23:1127.
  30. Bisulli F, Vignatelli L, Naldi I, et al. Increased frequency of arousal parasomnias in families with nocturnal frontal lobe epilepsy: a common mechanism? Epilepsia 2010; 51:1852.
  31. Macleod S, Ferrie C, Zuberi SM. Symptoms of narcolepsy in children misinterpreted as epilepsy. Epileptic Disord 2005; 7:13.
  32. Mihaescu M, Malow BA. Sleep disorders: a sometimes forgotten cause of nonepileptic spells. Epilepsy Behav 2003; 4:784.
  33. Galimberti CA, Ossola M, Colnaghi S, Arbasino C. Focal epileptic seizures mimicking sleep paralysis. Epilepsy Behav 2009; 14:562.
  34. Lugaresi E, Cirignotta F. Hypnogenic paroxysmal dystonia: epileptic seizure or a new syndrome? Sleep 1981; 4:129.
  35. Derry CP, Duncan JS, Berkovic SF. Paroxysmal motor disorders of sleep: the clinical spectrum and differentiation from epilepsy. Epilepsia 2006; 47:1775.
  36. Provini F, Plazzi G, Lugaresi E. From nocturnal paroxysmal dystonia to nocturnal frontal lobe epilepsy. Clin Neurophysiol 2000; 111 Suppl 2:S2.
  37. Hening WA, Allen RP, Earley CJ, et al. An update on the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. Sleep 2004; 27:560.
  38. O'Keeffe ST. Restless legs syndrome. A review. Arch Intern Med 1996; 156:243.
  39. Tinuper P, Provini F, Bisulli F, Lugaresi E. Hyperkinetic manifestations in nocturnal frontal lobe epilepsy. Semeiological features and physiopathological hypothesis. Neurol Sci 2005; 26 Suppl 3:s210.
  40. Walters AS. Clinical identification of the simple sleep-related movement disorders. Chest 2007; 131:1260.
  41. Anderson KN, Smith IE, Shneerson JM. Rhythmic movement disorder (head banging) in an adult during rapid eye movement sleep. Mov Disord 2006; 21:866.
  42. Hashizume Y, Yoshijima H, Uchimura N, Maeda H. Case of head banging that continued to adolescence. Psychiatry Clin Neurosci 2002; 56:255.
  43. Derry CP, Davey M, Johns M, et al. Distinguishing sleep disorders from seizures: diagnosing bumps in the night. Arch Neurol 2006; 63:705.
  44. Manni R, Terzaghi M, Repetto A. The FLEP scale in diagnosing nocturnal frontal lobe epilepsy, NREM and REM parasomnias: data from a tertiary sleep and epilepsy unit. Epilepsia 2008; 49:1581.
  45. Müller J, Wissel J, Masuhr F, et al. Clinical characteristics of the geste antagoniste in cervical dystonia. J Neurol 2001; 248:478.
  46. Demirkiran M, Jankovic J. Paroxysmal dyskinesias: clinical features and classification. Ann Neurol 1995; 38:571.
  47. Bruno MK, Hallett M, Gwinn-Hardy K, et al. Clinical evaluation of idiopathic paroxysmal kinesigenic dyskinesia: new diagnostic criteria. Neurology 2004; 63:2280.
  48. Lotze T, Jankovic J. Paroxysmal kinesigenic dyskinesias. Semin Pediatr Neurol 2003; 10:68.
  49. Bhatia KP. The paroxysmal dyskinesias. J Neurol 1999; 246:149.
  50. Sethi NK, Labar D, Torgovnick J. Myoclonic epilepsy masquerading as a tic disorder. Clin Neurol Neurosurg 2007; 109:509.
  51. Mahone EM, Bridges D, Prahme C, Singer HS. Repetitive arm and hand movements (complex motor stereotypies) in children. J Pediatr 2004; 145:391.
  52. Tan NC, Chan LL, Tan EK. Hemifacial spasm and involuntary facial movements. QJM 2002; 95:493.
  53. Port JD. Advanced magnetic resonance imaging techniques for patients with hemifacial spasm. Ophthal Plast Reconstr Surg 2002; 18:72.
  54. Defazio G, Abbruzzese G, Girlanda P, et al. Botulinum toxin A treatment for primary hemifacial spasm: a 10-year multicenter study. Arch Neurol 2002; 59:418.
  55. Hallett M. Blepharospasm: recent advances. Neurology 2002; 59:1306.
  56. Towfigh A, Mostofi N, Motamedi GK. Poststroke partial seizures presenting as hemifacial spasm. Mov Disord 2007; 22:1981.
  57. Arzimanoglou AA, Salefranque F, Goutières F, Aicardi J. Hemifacial spasm or subcortical epilepsy? Epileptic Disord 1999; 1:121.
  58. Espay AJ, Schmithorst VJ, Szaflarski JP. Chronic isolated hemifacial spasm as a manifestation of epilepsia partialis continua. Epilepsy Behav 2008; 12:332.
  59. Armon C, McEvoy KM, Westmoreland BF, McManis PG. Clinical neurophysiologic studies in stiff-man syndrome: use of simultaneous video-electroencephalographic-surface electromyographic recording. Mayo Clin Proc 1990; 65:960.
  60. Syvertsen M, Helde G, Stovner LJ, Brodtkorb E. Headaches add to the burden of epilepsy. J Headache Pain 2007; 8:224.
  61. Menon B. Symptomatic occipital epilepsy misdiagnosed as migraine. Headache 2007; 47:287.
  62. Panayiotopoulos CP. Elementary visual hallucinations, blindness, and headache in idiopathic occipital epilepsy: differentiation from migraine. J Neurol Neurosurg Psychiatry 1999; 66:536.
  63. Panayiotopoulos CP. Visual phenomena and headache in occipital epilepsy: a review, a systematic study and differentiation from migraine. Epileptic Disord 1999; 1:205.
  64. Andermann F, Zifkin B. The benign occipital epilepsies of childhood: an overview of the idiopathic syndromes and of the relationship to migraine. Epilepsia 1998; 39 Suppl 4:S9.
  65. Ito M, Adachi N, Nakamura F, et al. Characteristics of postictal headache in patients with partial epilepsy. Cephalalgia 2004; 24:23.
  66. Leniger T, Isbruch K, von den Driesch S, et al. Seizure-associated headache in epilepsy. Epilepsia 2001; 42:1176.
  67. Yankovsky AE, Andermann F, Bernasconi A. Characteristics of headache associated with intractable partial epilepsy. Epilepsia 2005; 46:1241.
  68. Förderreuther S, Henkel A, Noachtar S, Straube A. Headache associated with epileptic seizures: epidemiology and clinical characteristics. Headache 2002; 42:649.
  69. Cai S, Hamiwka LD, Wirrell EC. Peri-ictal headache in children: prevalence and character. Pediatr Neurol 2008; 39:91.
  70. Fanella M, Fattouch J, Casciato S, et al. Ictal epileptic headache as "subtle" symptom in generalized idiopathic epilepsy. Epilepsia 2012; 53:e67.
  71. Russell MB, Olesen J. A nosographic analysis of the migraine aura in a general population. Brain 1996; 119 ( Pt 2):355.
  72. Rubin D, McAbee GN, Feldman-Winter LB. Auditory hallucinations associated with migraine. Headache 2002; 42:646.
  73. Florindo I, Bisulli F, Pittau F, et al. Lateralizing value of the auditory aura in partial seizures. Epilepsia 2006; 47 Suppl 5:68.
  74. Korsnes MS, Hugdahl K, Nygård M, Bjørnaes H. An fMRI study of auditory hallucinations in patients with epilepsy. Epilepsia 2010; 51:610.
  75. Krabbendam L, van Os J. Schizophrenia and urbanicity: a major environmental influence--conditional on genetic risk. Schizophr Bull 2005; 31:795.
  76. Bianchi MT, Dworetzky BA, Bromfield EB. Auditory auras in patients with postencephalitic epilepsy: case series. Epilepsy Behav 2009; 14:250.
  77. Hurst RW, Lee SI. Ictal tinnitus. Epilepsia 1986; 27:769.
  78. Bisulli F, Tinuper P, Avoni P, et al. Idiopathic partial epilepsy with auditory features (IPEAF): a clinical and genetic study of 53 sporadic cases. Brain 2004; 127:1343.
  79. Ohayon MM. Prevalence of hallucinations and their pathological associations in the general population. Psychiatry Res 2000; 97:153.
  80. Widdess-Walsh P, Kotagal P, Jeha L, et al. Multiple auras: clinical significance and pathophysiology. Neurology 2007; 69:755.
  81. Lennox, WG, Cobb, S. Aura in epilepsy: a statistical review of 1359 cases. Arch Neurol Psychiatry 1933; 30:374.
  82. Shergill SS, Cameron LA, Brammer MJ, et al. Modality specific neural correlates of auditory and somatic hallucinations. J Neurol Neurosurg Psychiatry 2001; 71:688.
  83. Honig A, Romme MA, Ensink BJ, et al. Auditory hallucinations: a comparison between patients and nonpatients. J Nerv Ment Dis 1998; 186:646.
  84. Choong C, Hunter MD, Woodruff PW. Auditory hallucinations in those populations that do not suffer from schizophrenia. Curr Psychiatry Rep 2007; 9:206.
  85. Dauvilliers Y, Billiard M, Montplaisir J. Clinical aspects and pathophysiology of narcolepsy. Clin Neurophysiol 2003; 114:2000.
  86. Assal F, Cummings JL. Neuropsychiatric symptoms in the dementias. Curr Opin Neurol 2002; 15:445.
  87. Fénelon G, Thobois S, Bonnet AM, et al. Tactile hallucinations in Parkinson's disease. J Neurol 2002; 249:1699.
  88. Tousi B, Frankel M. Olfactory and visual hallucinations in Parkinson's disease. Parkinsonism Relat Disord 2004; 10:253.
  89. Bannier S, Berdagué JL, Rieu I, et al. Prevalence and phenomenology of olfactory hallucinations in Parkinson's disease. J Neurol Neurosurg Psychiatry 2012; 83:1019.
  90. Brady KT, Lydiard RB, Malcolm R, Ballenger JC. Cocaine-induced psychosis. J Clin Psychiatry 1991; 52:509.
  91. Evers S, Ellger T. The clinical spectrum of musical hallucinations. J Neurol Sci 2004; 227:55.
  92. Balasubramaniam B, Park GR. Sexual hallucinations during and after sedation and anaesthesia. Anaesthesia 2003; 58:549.
  93. Webster R, Holroyd S. Prevalence of psychotic symptoms in delirium. Psychosomatics 2000; 41:519.