Medline ® Abstract for Reference 32
Hyponatraemia and cerebral convulsion due to short term DDAVP therapy for control of enuresis nocturna.
Schwab M, Wenzel D, Ruder H
Eur J Pediatr. 1996;155(1):46.
UNLABELLED: Desmopressin (DDAVP) is frequently used in the treatment of primary isolated enuresis nocturna if other approaches have failed. We report a further case of hyponatraemia and cerebral convulsion due to water intoxication after intranasal DDAVP application by a 6 year-old boy with enuresis.
CONCLUSION: Although adverse reactions in DDAVP (e.g. hyponatraemia) are rare, it should not be considered as the first choice treatment of enuresis nocturna and only be used with caution.
Universitätskinderklinik, Erlangen, Germany.