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Medline ® Abstracts for References 1,3-5

of '自然杀伤细胞大颗粒淋巴细胞白血病'

1
TI
Clonal diseases of large granular lymphocytes.
AU
Loughran TP Jr
SO
Blood. 1993;82(1):1.
 
Three distinct clinical syndromes occur in patients with increased numbers of circulating LGL. Patients with T-LGL leukemia have clonal proliferations of CD3+ LGL typically associated with chronic neutropenia and autoimmune features. NK-LGL leukemia is characterized by clonal CD3- LGL proliferation with an acute clinical presentation marked by massive hepatosplenomegaly and systemic illness. However, most patients with increased numbers of CD3- LGL do not have clinical features of NK-LGL leukemia and have a chronic clinical course. X-linked gene analyses have supported a polyclonal LGL lymphocytosis in this syndrome. Further studies are needed to determine whether clonal progression can occur in these patients.
AD
Veterans Administration Hospital, Syracuse, NY 13210.
PMID
3
TI
Granular lymphocyte proliferative disorders: report of 12 cases and review of the literature.
AU
Oshimi K
SO
Leukemia. 1988;2(10):617.
 
AD
Department of Medicine, Tokyo Women's Medical College, Japan.
PMID
4
TI
Spectrum of diseases associated with increased proportions or absolute numbers of peripheral blood natural killer cells.
AU
Okuno SH, Tefferi A, Hanson CA, Katzmann JA, Li CY, Witzig TE
SO
Br J Haematol. 1996;93(4):810.
 
In a retrospective review of 1501 lymphoid flow cytometric studies of peripheral blood, we identified an increased proportion of natural killer cells in 125 cases (8%), 49 (3%) of which had a concomitant increase in absolute number of natural killer cells. Of the latter, the most frequent associated disorder was chronic natural killer cell lymphocytosis. Substantial quantitative increases in natural killer cells were also observed in some patients with lymphoma, leukaemia, immune thrombocytopenic purpura, or myelodysplastic syndrome. Our study provides incidence figures and clinical associations of an increased number of natural killer cells in the peripheral blood.
AD
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
PMID
5
TI
Haemophagocytic lymphohistiocytosis in association with granular lymphocyte proliferative disorders in early childhood: characteristic bone marrow morphology.
AU
Imashuku S, Hibi S, Morinaga S, Takagi K, Chen J, Mugishima H, Ishii T, Sako M, Arakawa H, Kato M
SO
Br J Haematol. 1997;96(4):708.
 
Five paediatric cases of haemophagocytic lymphohistiocytosis (HLH) which showed proliferation of granular atypical lymphocytoid cells in bone marrow are reported. All cases were girls aged 8 months to 4 years who had marked hepatosplenomegaly. Marker analysis on peripheral blood mononuclear cells revealed an increase in the CD3+HLADR+ subset in three cases and the CD3- CD56+ subset in one case. An Epstein-Barr virus genome was detected in three cases, and monoclonality was confirmed in two cases. A characteristic morphology of large granular lymphocytes (LGL) was identified, with elongated bizarre features that resembled horsetail-, tadpole-, cucumber- or shooting star-type configurations on the bone marrow smear. Serum concentrations of soluble interleukin-2 receptor and interferon-gamma were elevated in all cases. All five cases required multi-agent chemotherapy which resulted in two complete remission, two partial remissions and one no response. Refinement of treatment is required for these paediatric GLPD cases which probably comprise a specific high-risk subgroup among secondary HLH patients which had previously escaped notice.
AD
Division of Paediatrics, Children's Research Hospital, Kyoto Prefectural University of Medicine, Japan.
PMID