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复发性上皮性卵巢癌、输卵管癌或腹膜癌的药物治疗：铂类耐药型疾病

Authors
Michael J Birrer, MD, PhD
Keiichi Fujiwara, MD, PhD
Section Editors
Barbara Goff, MD
Don S Dizon, MD, FACP
Deputy Editor
Sadhna R Vora, MD
Translators
何畏, 主任医师，教授

引言

女性卵巢、输卵管及腹膜起源的上皮癌表现出相似的临床特征和行为。因此，在临床试验和临床实践中，这些上皮癌通常被统称为上皮性卵巢癌(epithelial ovarian cancer, EOC)。本专题将考虑EOC名下的所有3种肿瘤。

尽管接受了初始治疗，大多数女性患者将复发，且需要再治疗。考虑到各期疾病的发生率及预计复发率，所有分期EOC女性初始治疗后的总复发可能性为62%；如果出现腹腔病变(Ⅲ期)或腹腔外病变(如肝脏或肺受累，Ⅳ期)，患者的复发可能性为80%-85%。

根据完成以铂类为基础的治疗至发现复发的时间间隔[称为无铂治疗间期(platinum-free interval, PFI)]，对复发病变的治疗进行分层(参见“First-line chemotherapy for advanced (stage III or IV) epithelial ovarian, fallopian tubal, and peritoneal cancer”, section on ‘Treatment of recurrent disease’)：

●PFI大于等于6个月的患者被认为患“铂类敏感型”疾病。这类患者的治疗将单独讨论。 (参见“复发性上皮性卵巢癌、输卵管癌或腹膜癌的药物治疗:铂类敏感型疾病”)

●PFI小于6个月的患者被认为患“铂类耐药型”疾病。该组患者包括在以铂类为基础的一线治疗期间疾病进展的女性，通常称有“铂类难治性”疾病。本专题将讨论这些患者(统称为铂类耐药型EOC)的治疗。

                          

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Literature review current through: 2017-06 . | This topic last updated: 2017-02-16.
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