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肥厚型心肌病的自然病程

Authors
Martin S Maron, MD
Perry M Elliott, MD
Section Editor
William J McKenna, MD
Deputy Editor
Brian C Downey, MD, FACC
Translators
田庄, 副主任医师，副教授

引言

肥厚型心肌病(Hypertrophic cardiomyopathy, HCM)是一种遗传基因决定的心肌疾病，由编码收缩装置组分的多个肌节基因中某个基因发生突变所致。 (参见“肥厚型心肌病的遗传学”)

HCM的特点是表型表达和临床病程均有较大的多样性(图 1)。左心室肥厚(left ventricular hypertrophy, LVH)的部位、形态和程度不尽相同，但最常见的室壁增厚部位是与前游离壁连续的前间隔基底段。HCM患者可发生以下一种或几种形态异常：

●左室流出道梗阻(参见“梗阻性肥厚型心肌病的类型与病理生理学”)

●舒张功能障碍

●心肌缺血

                    

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Literature review current through: 2017-06 . | This topic last updated: 2017-02-22.
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