Medline ® Abstract for Reference 37
1,25-dihydroxyvitamin D-mediated hypercalcemia in ovarian dysgerminoma.
Hibi M, Hara F, Tomishige H, Nishida Y, Kato T, Okumura N, Hashimoto T, Kato R
Pediatr Hematol Oncol. 2008;25(1):73.
Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25-dihydroxyvitamin D. HHM is extremely resistant to medical therapy. Therefore, tumor resection or volume reduction is necessary to control serum calcium levels.
Department of Pediatric Surgery, Fujita Health University, Toyoake, Aichi, Japan. email@example.com