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Medline ® Abstracts for References 1,2,5,6

of '恶性肿瘤高钙血症'

1
TI
Clinical practice. Hypercalcemia associated with cancer.
AU
Stewart AF
SO
N Engl J Med. 2005;352(4):373.
 
AD
Division of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh 15213, USA. stewart@dom.pitt.edu
PMID
2
TI
Calcitriol: the major humoral mediator of hypercalcemia in Hodgkin's disease and non-Hodgkin's lymphomas.
AU
Seymour JF, Gagel RF
SO
Blood. 1993;82(5):1383.
 
AD
Department of Medical Specialties, M.D. Anderson Cancer Center, University of Texas, Houston.
PMID
5
TI
Hypercalcemia in breast cancer.
AU
Francini G, Petrioli R, Maioli E, Gonnelli S, Marsili S, Aquino A, Bruni S
SO
Clin Exp Metastasis. 1993;11(5):359.
 
Hypercalcemia is relatively frequent in malignancy with or without osteolytic bone metastases. It is thought that neoplastic cells may secrete substances which not only stimulate osteoclastic activity but are also capable of modifying the absorption, excretion, and resorption of calcium and phosphate ions. Since 1987, we have studied 24 breast cancer patients with hypercalcemia (22 with bone metastases and two without). The group of 22 patients with bone metastases were divided into two subgroups. The first consisted of 10 patients with high serum levels of humoral factors, such as parathyroid hormone-related protein (PTHrP), and/or prostaglandin E2 (PGE2) and/or interleukin 1 (IL-1), and high levels of bone markers, such as alkaline phosphatase, bone Gla protein and urinary hydroxyproline. The second subgroup consisted of 12 patients with high levels of bone markers alone. Bone histologic analysis showed an osteoclastic activation surrounding metastatic tumor tissue in six out of 10 patients of the first subgroup, while an evident osteolysis caused by the tumor cells was noted in seven out of 12 patients of the second subgroup. The two patients without bone metastases showed normal biochemistry and bone histologic examination. The authors, having tried to explain the pathogenesis of hypercalcemia, emphasize the importance of humoral factors secreted by tumor cells as a direct or indirect cause of hypercalcemia. The origin of hypercalcemia remains unclear in two patients without bone metastases.
AD
Institute of Medical Pathology, University of Siena, Italy.
PMID
6
TI
Metastasis to bone: causes, consequences and therapeutic opportunities.
AU
Mundy GR
SO
Nat Rev Cancer. 2002;2(8):584.
 
The most common human cancers --lung, breast and prostate -- have a great avidity for bone, leading to painful and untreatable consequences. What makes some cancers, but not others, metastasize to bone, and how do they alter its physiology? Some of the molecular mechanisms that are responsible have recently been identified, and provide new molecular targets for drug development.
AD
Department of Molecular Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, MS 7877, San Antonio, Texas 78229-3900, USA. mundy@uthscsa.edu
PMID