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Medline ® Abstract for Reference 14

of '胰高血糖素瘤和胰高血糖素瘤综合征'

Glucagonoma diagnosed by arterial stimulation and venous sampling (ASVS).
Okauchi Y, Nammo T, Iwahashi H, Kizu T, Hayashi I, Okita K, Yamagata K, Uno S, Katsube F, Matsuhisa M, Kato K, Aozasa K, Kim T, Osuga K, Nakamori S, Tamaki Y, Funahashi T, Miyagawa J, Shimomura I
Intern Med. 2009;48(12):1025. Epub 2009 Jun 15.
To identify the location of pancreatic endocrine tumors, arterial stimulation and venous sampling (ASVS) is known to be useful for insulinoma and gastrinoma, but its usefulness for glucagonoma has not been verified to date. Here we report a case of glucagonoma that was diagnosed by ASVS with calcium loading, in which an approximately 6-fold increase of glucagon was observed in the splenic artery territory. MEN1 gene analysis verified the presence of a mutation and the glucagonoma was confirmed after operation. In conclusion, ASVS could be useful for the diagnosis of glucagonoma.
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita. okauchi@imed2.med.osaka-u.ac.jp